Using biologically synthesized TiO2 nanoparticles as potential remedy against multiple drug resistant Staphylococcus aureus of bovine mastitis

Presently, there is considerable emphasis on biological synthesis of nanoparticles containing bioactive reducing compounds with an aim to mitigate the harmful effects of pollutants. The approach under study is simple and ideal for the production of durable antimicrobial nanomaterials by novel single...

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Bibliographic Details
Published in:Scientific reports 2023-11, Vol.13 (1), p.18785-18785, Article 18785
Main Authors: Ul-Hamid, Anwar, Baig, Nadeem, Haider, Ali, Hakeem, Abbas S., Ikram, Muhammad
Format: Article
Language:English
Subjects:
639/301
639/925
Drug resistance
Humanities and Social Sciences
Mastitis
Methylene blue
multidisciplinary
Multidrug resistance
Nanomaterials
Nanoparticles
Nanotechnology
Pollution effects
Science
Science (multidisciplinary)
Spectroscopy
Titanium dioxide
X-ray diffraction
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Summary:Presently, there is considerable emphasis on biological synthesis of nanoparticles containing bioactive reducing compounds with an aim to mitigate the harmful effects of pollutants. The approach under study is simple and ideal for the production of durable antimicrobial nanomaterials by novel single-step green synthesis of TiO 2 metal oxide nanostructures using ginger and garlic crude aqueous extracts with bactericidal and catalytic activity. A variety of experimental techniques were used to characterize the synthesized nanomaterials. As demonstrated using x-ray diffraction and ultra-violet visible spectroscopy, the produced nanoparticles exhibited high absorption at 318 nm with size varying between 23.38 nm for ginger and 58.64 nm for garlic in biologically-reduced TiO 2 . At increasing concentrations (500, 1000 µg/50 µl), nanoparticles reduced with garlic exhibited enhanced bactericidal efficacy against multiple drug-resistant S. aureus and effectively decomposed toxic methylene blue (MB) dye. In conclusion, biologically-reduced TiO 2 nanoparticles may prove an effective tool in the fight against microbial illnesses and drug resistance.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-45762-4