Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis

Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated tha...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2013, Vol.4, p.109-109
Main Authors: Gubar, Olga, Morderer, Dmytro, Tsyba, Lyudmila, Croisé, Pauline, Houy, Sébastien, Ory, Stéphane, Gasman, Stéphane, Rynditch, Alla
Format: Article
Language:English
Subjects:
Cdc42
Endocrinology
Endocytosis
Exocytosis
Life Sciences
Neurobiology
Neuroendocrine Cells
Neurons
Neurons and Cognition
Scaffold
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Summary:Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2013.00109