Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise ( Illicium verum ) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

• Published in: Antioxidants 2022-11, Vol.11 (11), p.2240
• Main Authors: Iftikhar, Neelam, Hussain, Abdullah Ijaz, Kamal, Ghulam Mustafa, Manzoor, Sidra, Fatima, Tabinda, Alswailmi, Farhan Khashim, Ahmad, Ashfaq, Alsuwayt, Bader, Abdullah Alnasser, Sulaiman Mohammed
• Format: Article
• Language: English
• Subjects: Acids; BMI; Body mass index; Body weight; Catechin; Chlorogenic acid; Cholesterol; Coronaviruses; COVID-19; Diabetes; Diet; Ferulic acid; Flavonoids; Free radicals; HDL; High fat diet; Illicium verum; kidney index; Kidneys; Lipoproteins (very low density); Liquid chromatography; liver index; Low density lipoprotein; Natural products; Nutritional aspects; Obesity; Overweight; Oxidative stress; Phenolic acids; Polyphenols; Rutin; Severe acute respiratory syndrome coronavirus 2; Tea; VLDL; Weight control
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox11112240

Star anise (Illicium verum Hook. fil.) is commonly utilized as a culinary and medicinal fruit and is most famous in indigenous systems of medicine. The present research work aims to appraise and validate the potential of polyphenol-rich star anise tea (SAT) on oxidative stress, obesity and related biochemical parameters in high-fat-sugar-diet (HFSD)-induced obesity model in rats. SAT was prepared using the traditional method in warm water. The Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis was performed for the simultaneous determination of phenolic acids and flavonoids in SAT. Two doses (250 and 500 mg/kg body weight) were selected to investigate the anti-obesity potential of SAT using HFSD-induced obese rat model. Major (>5 mg/100 mL) phenolic acids in SAT were p-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid while catechin and rutin were the major flavonoids detected in the SAT. SAT exhibited 51.3% DPPH radical scavenging activity. In vivo study showed that higher doses of SAT (500 mg/kg body weight) significantly reduced the body weight increase (74.82%) and BMI (0.64 g/cm2). Moreover, significant reductions in the levels of serum total cholesterol, triglyceride, LDL and VLDL were recorded in all the treatment groups in comparison to the HFSDC group. Furthermore, SAT reduced the alterations in MDA, SOD and GSH levels of experimental groups thus showing the potential against oxidative stress. The SAT-500 group showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison to the HFSDC group. The present study proved that SAT exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.