Contribution of In Vivo and Organotypic 3D Models to Understanding the Role of Macrophages and Neutrophils in the Pathogenesis of Psoriasis

Psoriasis, a common chronic immune-mediated skin disease, is histologically characterized by a rapid keratinocyte turnover and differentiation defects. Key insights favor the idea that T cells are not the only key actors involved in the inflammatory process. Innate immune cells, more precisely neutr...

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Bibliographic Details
Published in:Mediators of inflammation 2017-01, Vol.2017 (2017), p.1-13
Main Authors: Pouliot, Roxane, Seyler, Nathalie, Asselineau, Daniel, Lorthois, Isabelle
Format: Article
Language:English
Subjects:
Animal models
Animals
Antigens
Chemokines
Chromosomes
Dendritic cells
Dermatology
Development and progression
Disease
Genes
Health aspects
Humans
Inflammation
Leukocytes (neutrophilic)
Lymphocytes
Lymphocytes T
Macrophages
Macrophages - metabolism
Neutrophils
Neutrophils - metabolism
Pathogenesis
Phenotypes
Physiological aspects
Psoriasis
Psoriasis - metabolism
Psoriasis - pathology
Review
Skin
Skin - metabolism
Skin - pathology
Skin diseases
Studies
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Summary:Psoriasis, a common chronic immune-mediated skin disease, is histologically characterized by a rapid keratinocyte turnover and differentiation defects. Key insights favor the idea that T cells are not the only key actors involved in the inflammatory process. Innate immune cells, more precisely neutrophils and macrophages, provide specific signals involved in the initiation and the maintenance of the pathogenesis. Current data from animal models and, to a lesser extent, three-dimensional in vitro models have confirmed the interest in leaning towards other immune cell types as a potential new cellular target for the treatment of the disease. Although these models do not mimic the complex phenotype nor all human features of psoriasis, their development is necessary and essential to better understand reciprocal interactions between skin cells and innate immune cells and to emphasize the crucial importance of the local lesional microenvironment. In this review, through the use of in vivo and 3D organotypic models, we aim to shed light on the crosstalk between epithelial and immune components and to discuss the role of secreted inflammatory molecules in the development of this chronic skin disease.
ISSN:0962-9351
1466-1861
DOI:10.1155/2017/7215072