Intraoperative Quantitative Measurements for Bradykinesia Evaluation during Deep Brain Stimulation Surgery Using Leap Motion Controller: A Pilot Study

Deep brain stimulation (DBS) has shown a remarkably high effectiveness for Parkinson's disease (PD). In many PD patients during DBS surgery, the therapeutic effects of the stimulation test are estimated by assessing changes in bradykinesia as the stimulation voltage is increased. In this study,...

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Bibliographic Details
Published in:Parkinson's disease 2021, Vol.2021, p.1-7
Main Authors: Wu, Jingchao, Yu, Ningbo, Yu, Yang, Li, Haitao, Wu, Fan, Yang, Yuchen, Lin, Jianeng, Han, Jianda, Liang, Siquan
Format: Article
Language:English
Subjects:
Brain
Deep brain stimulation
Electrical stimuli
Hand
Health aspects
Motor task performance
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Patients
Sensors
Software
Statistical analysis
Subthalamic nucleus
Surgery
Tremor (Muscular contraction)
User interface
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Summary:Deep brain stimulation (DBS) has shown a remarkably high effectiveness for Parkinson's disease (PD). In many PD patients during DBS surgery, the therapeutic effects of the stimulation test are estimated by assessing changes in bradykinesia as the stimulation voltage is increased. In this study, we evaluated the potential of the leap motion controller (LMC) to quantify the motor component of bradykinesia in PD during DBS surgery, as this could make the intraoperative assessment of bradykinesia more accurate. Seven participants with idiopathic PD receiving chronic bilateral subthalamic nucleus deep brain stimulation (DBS) therapy were recruited. The motor tasks of finger tapping (FT), hand opening and closing (OC), and hand pronation and supination (PS) were selected pre- and intraoperatively in accordance with the Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale. During the test, participants performed these tasks in sequence while being simultaneously monitored by the LMC and two professional clinicians. Key kinematic parameters differed between the preoperative and intraoperative conditions. We suggest that the average velocity (V¯) and average amplitude (A¯) of PS isolate the bradykinetic feature from that movement to provide a measure of the intraoperative state of the motor system. The LMC achieved promising results in evaluating PD patients’ hand and finger bradykinesia during DBS surgery.
ISSN:2090-8083
2042-0080
DOI:10.1155/2021/6639762