Structure of Spectral Composition and Synchronization in Human Sleep on the Whole Scalp: A Pilot Study

• Published in: Brain sciences 2024-10, Vol.14 (10), p.1007
• Main Authors: Pastor, Jesús, Garrido Zabala, Paula, Vega-Zelaya, Lorena
• Format: Article
• Language: English
• Subjects: Activity patterns; Analysis; Bandwidths; bipolar montage; coherence; Electrocardiography; Electrodes; Electroencephalography; Electromyography; Epilepsy; Eye movements; fast Fourier transform; Frontal lobe; Heart rate; K-complex; Mathematical models; Medical research; Medicine, Experimental; NREM sleep; Numerical analysis; Occipital lobe; Pearson’s correlation coefficient; Physiology; polysomnography; REM sleep; Scalp; Sleep; Sleep and wakefulness; Synchronization
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci14101007

We used numerical methods to define the normative structure of the different stages of sleep and wake (W) in a pilot study of 19 participants without pathology (18-64 years old) using a double-banana bipolar montage. Artefact-free 120-240 s epoch lengths were visually identified and divided into 1 s windows with a 10% overlap. Differential channels were grouped into frontal, parieto-occipital, and temporal lobes. For every channel, the power spectrum (PS) was calculated via fast Fourier transform and used to compute the areas for the delta (0-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) bands, which were log-transformed. Furthermore, Pearson's correlation coefficient and coherence by bands were computed. Differences in logPS and synchronization from the whole scalp were observed between the sexes for specific stages. However, these differences vanished when specific lobes were considered. Considering the location and stages, the logPS and synchronization vary highly and specifically in a complex manner. Furthermore, the average spectra for every channel and stage were very well defined, with phase-specific features (e.g., the sigma band during N2 and N3, or the occipital alpha component during wakefulness), although the slow alpha component (8.0-8.5 Hz) persisted during NREM and REM sleep. The average spectra were symmetric between hemispheres. The properties of K-complexes and the sigma band (mainly due to sleep spindles-SSs) were deeply analyzed during the NREM N2 stage. The properties of the sigma band are directly related to the density of SSs. The average frequency of SSs in the frontal lobe was lower than that in the occipital lobe. In approximately 30% of the participants, SSs showed bimodal components in the anterior regions. qEEG can be easily and reliably used to study sleep in healthy participants and patients.