Alanine Aminotransferase Level: The Road to Normal in 2021

Subjects’ age, sex, metabolic risk factors (hypertension, elevated body mass index [BMI], triglycerides, glucose, and total cholesterol), ferritin, recreational drug use, and significant physical activity were independently associated with ALT level. Another potential difficulty in defining the URL...

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Published in:Hepatology communications 2021-11, Vol.5 (11), p.1807-1809
Main Authors: Yip, Terry Cheuk‐Fung, Wong, Vincent Wai‐Sun, Wong, Grace Lai‐Hung
Format: Article
Language:English
Subjects:
Alanine Transaminase
Body mass index
Drug use
Hepatitis
Hyperglycemia
Interferon alpha-2
Interferon-alpha
Liver cancer
Liver diseases
Metabolism
Normal distribution
Population
Risk factors
Triglycerides
URLs
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description Subjects’ age, sex, metabolic risk factors (hypertension, elevated body mass index [BMI], triglycerides, glucose, and total cholesterol), ferritin, recreational drug use, and significant physical activity were independently associated with ALT level. Another potential difficulty in defining the URL is the generalizability in other populations. [...]Valenti et al. validated the URL in several independent cohorts on its ability to discriminate steatohepatitis and clinically significant fibrosis. For examples, in patients with chronic hepatitis B, more patients would have fulfilled the treatment criteria of ALT above 2 times the URL; this would contribute to the hepatitis elimination campaign by bringing down the incidence of deaths secondary to hepatocellular carcinoma and other cirrhotic complications.
doi_str_mv 10.1002/hep4.1788
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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Alanine Transaminase
Body mass index
Drug use
Hepatitis
Hyperglycemia
Interferon alpha-2
Interferon-alpha
Liver cancer
Liver diseases
Metabolism
Normal distribution
Population
Risk factors
Triglycerides
URLs
title Alanine Aminotransferase Level: The Road to Normal in 2021
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