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Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice
Hyperbilirubinaemia is a prevalent condition during the neonatal period, and if not promptly and effectively managed, it can lead to severe bilirubin-induced neurotoxicity. Sunflower seeds are a nutrient-rich food source, particularly abundant in linoleic acid. Here, we provide compelling evidence t...
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| Published in: | Cell death discovery 2024-07, Vol.10 (1), p.329-12, Article 329 |
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| creator | Yan, Ding Wu, XinTian Chen, Xi Wang, Jiangtuan Ge, Feifei Wu, Meixuan Wu, Jiawen Zhang, Na Xiao, Min Wu, Xueheng Xue, Qian Li, Xiaofen Chen, Jinghong Wang, Ping Tang, Daolin Wang, Xin Chen, Xin Liu, Jinbao |
| description | Hyperbilirubinaemia is a prevalent condition during the neonatal period, and if not promptly and effectively managed, it can lead to severe bilirubin-induced neurotoxicity. Sunflower seeds are a nutrient-rich food source, particularly abundant in linoleic acid. Here, we provide compelling evidence that lactating maternal mice fed a sunflower seed diet experience enhanced neurological outcomes and increased survival rates in hyperbilirubinemic offspring. We assessed histomorphological indices, including cerebellar Nissl staining, and Calbindin staining, and hippocampal hematoxylin and eosin staining. Furthermore, we observed the transmission of linoleic acid, enriched in sunflower seeds, to offspring through lactation. The oral administration of linoleic acid-rich sunflower seed oil by lactating mothers significantly prolonged the survival time of hyperbilirubinemic offspring mice. Mechanistically, linoleic acid counteracts the bilirubin-induced accumulation of ubiquitinated proteins and neuronal cell death by activating autophagy. Collectively, these findings elucidate the novel role of a maternal linoleic acid-supplemented diet in promoting child health. |
| doi_str_mv | 10.1038/s41420-024-02099-9 |
| format | article |
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Sunflower seeds are a nutrient-rich food source, particularly abundant in linoleic acid. Here, we provide compelling evidence that lactating maternal mice fed a sunflower seed diet experience enhanced neurological outcomes and increased survival rates in hyperbilirubinemic offspring. We assessed histomorphological indices, including cerebellar Nissl staining, and Calbindin staining, and hippocampal hematoxylin and eosin staining. Furthermore, we observed the transmission of linoleic acid, enriched in sunflower seeds, to offspring through lactation. The oral administration of linoleic acid-rich sunflower seed oil by lactating mothers significantly prolonged the survival time of hyperbilirubinemic offspring mice. Mechanistically, linoleic acid counteracts the bilirubin-induced accumulation of ubiquitinated proteins and neuronal cell death by activating autophagy. Collectively, these findings elucidate the novel role of a maternal linoleic acid-supplemented diet in promoting child health.</description><identifier>ISSN: 2058-7716</identifier><identifier>EISSN: 2058-7716</identifier><identifier>DOI: 10.1038/s41420-024-02099-9</identifier><identifier>PMID: 39030174</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/1934 ; 692/699/375 ; Apoptosis ; Autophagy ; Bilirubin ; Biochemistry ; Biomedical and Life Sciences ; Breastfeeding & lactation ; Calbindin ; Cell Biology ; Cell Cycle Analysis ; Cell death ; Cerebellum ; Cytotoxicity ; Diet ; Fatalities ; Food sources ; Helianthus ; Hippocampus ; Lactation ; Life Sciences ; Linoleic acid ; Medical research ; Mothers ; Neonates ; Neurotoxicity ; Offspring ; Oral administration ; Oxidative stress ; Pregnancy ; Seeds ; Stem Cells</subject><ispartof>Cell death discovery, 2024-07, Vol.10 (1), p.329-12, Article 329</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-d7321741a3407a1e51924715eff73957165d8d3c2494ffe4ecfd18c1f88081e43</cites><orcidid>0000-0003-2220-2407 ; 0000-0003-3668-4830 ; 0000-0002-1903-6180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271588/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271588/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39030174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Ding</creatorcontrib><creatorcontrib>Wu, XinTian</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>Wang, Jiangtuan</creatorcontrib><creatorcontrib>Ge, Feifei</creatorcontrib><creatorcontrib>Wu, Meixuan</creatorcontrib><creatorcontrib>Wu, Jiawen</creatorcontrib><creatorcontrib>Zhang, Na</creatorcontrib><creatorcontrib>Xiao, Min</creatorcontrib><creatorcontrib>Wu, Xueheng</creatorcontrib><creatorcontrib>Xue, Qian</creatorcontrib><creatorcontrib>Li, Xiaofen</creatorcontrib><creatorcontrib>Chen, Jinghong</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Tang, Daolin</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Liu, Jinbao</creatorcontrib><title>Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice</title><title>Cell death discovery</title><addtitle>Cell Death Discov</addtitle><addtitle>Cell Death Discov</addtitle><description>Hyperbilirubinaemia is a prevalent condition during the neonatal period, and if not promptly and effectively managed, it can lead to severe bilirubin-induced neurotoxicity. 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Collectively, these findings elucidate the novel role of a maternal linoleic acid-supplemented diet in promoting child health.</description><subject>631/378/1934</subject><subject>692/699/375</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Bilirubin</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Breastfeeding & lactation</subject><subject>Calbindin</subject><subject>Cell Biology</subject><subject>Cell Cycle Analysis</subject><subject>Cell death</subject><subject>Cerebellum</subject><subject>Cytotoxicity</subject><subject>Diet</subject><subject>Fatalities</subject><subject>Food sources</subject><subject>Helianthus</subject><subject>Hippocampus</subject><subject>Lactation</subject><subject>Life Sciences</subject><subject>Linoleic acid</subject><subject>Medical research</subject><subject>Mothers</subject><subject>Neonates</subject><subject>Neurotoxicity</subject><subject>Offspring</subject><subject>Oral 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| subjects | 631/378/1934 692/699/375 Apoptosis Autophagy Bilirubin Biochemistry Biomedical and Life Sciences Breastfeeding & lactation Calbindin Cell Biology Cell Cycle Analysis Cell death Cerebellum Cytotoxicity Diet Fatalities Food sources Helianthus Hippocampus Lactation Life Sciences Linoleic acid Medical research Mothers Neonates Neurotoxicity Offspring Oral administration Oxidative stress Pregnancy Seeds Stem Cells |
| title | Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice |
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