Robust SERS Platforms Based on Annealed Gold Nanostructures Formed on Ultrafine Glass Substrates for Various (Bio)Applications

In this study, stable gold nanoparticles (AuNPs) are fabricated for the first time on commercial ultrafine glass coverslips coated with gold thin layers (2 nm, 4 nm, 6 nm, and 8 nm) at 25 °C and annealed at high temperatures (350 °C, 450 °C, and 550 °C) on a hot plate for different periods of time....

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Bibliographic Details
Published in:Biosensors 2019-04, Vol.9 (2), p.53
Main Authors: Zhou, Lan, Poggesi, Simone, Casari Bariani, Giuliocesare, Mittapalli, Rakesh, Adam, Pierre-Michel, Manzano, Marisa, Ionescu, Rodica Elena
Format: Article
Language:English
Subjects:
annealed gold nanostructures
Annealing
Aqueous solutions
Bioassays
BPE
Deoxyribonucleic acid
DNA
Engineering Sciences
Ethene
Ethylene
glass coverslips
Glass substrates
Gold
High temperature
Lasers
Morphology
Nanoparticles
Platforms
Raman spectroscopy
SERS on ultrafine solid supports
Signal and Image processing
Silicon nitride
Thin films
thiol-DNA probe
Ultrafines
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Summary:In this study, stable gold nanoparticles (AuNPs) are fabricated for the first time on commercial ultrafine glass coverslips coated with gold thin layers (2 nm, 4 nm, 6 nm, and 8 nm) at 25 °C and annealed at high temperatures (350 °C, 450 °C, and 550 °C) on a hot plate for different periods of time. Such gold nanostructured coverslips were systematically tested via surface enhanced Raman spectroscopy (SERS) to identify their spectral performances in the presence of different concentrations of a model molecule, namely 1,2-bis-(4-pyridyl)-ethene (BPE). By using these SERS platforms, it is possible to detect BPE traces (10 M) in aqueous solutions in 120 s. The stability of SERS spectra over five weeks of thiol-DNA probe (2 µL) deposited on gold nano-structured coverslip is also reported.
ISSN:2079-6374
0265-928X
2079-6374
DOI:10.3390/bios9020053