Curcumin and Mesenchymal Stem Cells Ameliorate Ankle, Testis, and Ovary Deleterious Histological Changes in Arthritic Rats via Suppression of Oxidative Stress and Inflammation

Rheumatoid arthritis (RA) is a chronic inflammatory condition, an autoimmune disease that affects the joints, and a multifactorial disease that results from interactions between environmental, genetic, and personal and lifestyle factors. This study was designed to assess the effects of curcumin, bon...

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Bibliographic Details
Published in:Stem cells international 2021, Vol.2021, p.1-20
Main Authors: Ahmed, Rania H., Galaly, Sanaa R., Moustafa, Nadia, Ahmed, Rasha Rashad, Ali, Tarek M., Elesawy, Basem H., Ahmed, Osama M., Abdul-Hamid, Manal
Format: Article
Language:English
Subjects:
Animals
Ankle
Antioxidants
Arthritis
Autoimmune diseases
Bioindicators
Bone marrow
Cartilage
Cellulose
Curcumin
Cytokines
Disease
Females
Immunomodulation
Indicator species
Inflammation
Interleukin 10
Intravenous administration
Joint diseases
Joints (anatomy)
Laboratories
Mesenchymal stem cells
Ovaries
Oxidative stress
Rheumatoid arthritis
Rheumatoid factor
Stem cell research
Stem cell transplantation
Stem cells
Testes
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Rheumatoid arthritis (RA) is a chronic inflammatory condition, an autoimmune disease that affects the joints, and a multifactorial disease that results from interactions between environmental, genetic, and personal and lifestyle factors. This study was designed to assess the effects of curcumin, bone marrow-derived mesenchymal stem cells (BM-MSCs), and their coadministration on complete Freund’s adjuvant- (CFA-) induced arthritis in male and female albino rats. Parameters including swelling of the joint, blood indices of pro-/antioxidant status, cytokines and histopathological examination of joints, and testis and ovary were investigated. RA was induced by a single dose of subcutaneous injection of 0.1 mL CFA into a footpad of the right hind leg of rats. Arthritic rats were treated with curcumin (100 mg/kg b.wt./day) by oral gavage for 21 days and/or treated with three weekly intravenous injections of BM-MSCs (1×106 cells/rat/week) in phosphate-buffered saline (PBS). The treatment with curcumin and BM-MSCs singly or together significantly (P
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2021/3516834