Added Value of CCTA-Derived Features to Predict MACEs in Stable Patients Undergoing Coronary Computed Tomography

Clinical evidence has emphasized the importance of coronary plaques’ characteristics, rather than lumen stenosis, for the outcome of cardiovascular events. Coronary computed tomographic angiography (CCTA) has a well-established role as a non-invasive tool for assessing plaques. The aim of this study...

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Published in:Diagnostics (Basel) 2022-06, Vol.12 (6), p.1446
Main Authors: Pergola, Valeria, Cabrelle, Giulio, Mattesi, Giulia, Cattarin, Simone, Furlan, Antonio, Dellino, Carlo Maria, Continisio, Saverio, Montonati, Carolina, Giorgino, Adelaide, Giraudo, Chiara, Leoni, Loira, Bariani, Riccardo, Barbiero, Giulio, Bauce, Barbara, Mele, Donato, Perazzolo Marra, Martina, De Conti, Giorgio, Iliceto, Sabino, Motta, Raffaella
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Body fat
Calcification
Cardiovascular disease
coronary computed tomography angiography
Coronary vessels
Heart attacks
low attenuation plaque
major adverse cardiac events
Mortality
Pain
Patients
pericoronary fat attenuation index
Physicians
plaque analysis
Statistical analysis
Tomography
Vein & artery diseases
Work stations
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Summary:Clinical evidence has emphasized the importance of coronary plaques’ characteristics, rather than lumen stenosis, for the outcome of cardiovascular events. Coronary computed tomographic angiography (CCTA) has a well-established role as a non-invasive tool for assessing plaques. The aim of this study was to compare clinical characteristics and CCTA-derived information of stable patients with non-severe plaques in predicting major adverse cardiac events (MACEs) during follow-up. We retrospectively selected 371 patients (64% male) who underwent CCTA in our center from March 2016 to January 2021 with Coronary Artery Disease—Reporting and Data System (CAD-RADS) 0 to 3. Of those, 198 patients (53% male) had CAD-RADS 0 to 1. Among them, 183 (49%) had normal pericoronary fat attenuation index (pFAI), while 15 (60% male) had pFAI ≥ 70.1 Hounsfield unit (HU). The remaining 173 patients (76% male) had CAD-RADS 2 to 3 and were divided into patients with at least one low attenuation plaque (LAP) and patients without LAPs (n-LAP). Compared to n-LAP, patients with LAPs had higher pFAI (p = 0.005) and had more plaques than patients with n-LAP. Presence of LAPs was significantly higher in elderly (p < 0.001), males (p < 0.001) and patients with traditional risk factors (hypertension p = 0.0001, hyperlipemia p = 0.0003, smoking p = 0.0003, diabetes p =
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12061446