SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Limited knowledge exists in post-partum women regarding durability of SARS-CoV-2 vaccine-induced antibody responses and their neutralising ability against SARS-CoV-2 variants of concern (VOC). We elucidated longitudinal mRNA vaccination-induced antibody profiles of 13 post-partum and 13 non-post-par...

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Bibliographic Details
Published in:EBioMedicine 2022-03, Vol.77, p.103940-103940, Article 103940
Main Authors: Lee, Youri, Grubbs, Gabrielle, Ramelli, Sabrina C., Levine, Andrea R., Bathula, Allison, Saharia, Kapil, Purcell, Madeleine, Singireddy, Shreya, Dugan, Colleen L., Kirchoff, Lindsey, Lankford, Allison, Cipriano, Sarah, Curto, Ryan A., Wu, Jocelyn, Raja, Katherine, Kelley, Emily, Herr, Daniel, Vannella, Kevin M., Ravichandran, Supriya, Tang, Juanjie, Harris, Anthony, Sajadi, Mohammad, Chertow, Daniel S., Grazioli, Alison, Khurana, Surender
Format: Article
Language:English
Subjects:
Affinity maturation
Antibodies, Viral
Antibody Affinity
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
Female
Humans
Immunoglobulin G
mRNA Vaccines
Neutralisation
Postpartum Period
SARS-CoV-2
SARS-CoV-2 - genetics
Spike
Vaccine
Vaccines, Synthetic
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Summary:Limited knowledge exists in post-partum women regarding durability of SARS-CoV-2 vaccine-induced antibody responses and their neutralising ability against SARS-CoV-2 variants of concern (VOC). We elucidated longitudinal mRNA vaccination-induced antibody profiles of 13 post-partum and 13 non-post-partum women (control). The antibody neutralisation titres against SARS-CoV-2 WA-1 strain were comparable between post-partum and non-post-partum women and these levels were sustained up to four months post-second vaccination in both groups. However, neutralisation titers declined against several VOCs, including Beta and Delta. Higher antibody binding was observed against SARS-CoV-2 receptor-binding domain (RBD) mutants with key VOC amino acids when tested with post-second vaccination plasma from post-partum women compared with controls. Importantly, post-vaccination plasma antibody affinity against VOCs RBDs was significantly higher in post-partum women compared with controls. This study demonstrates that there is a differential vaccination-induced immune responses in post-partum women compared with non-post-partum women, which could help inform future vaccination strategies for these groups. The antibody characterisation work described in this manuscript was supported by FDA's Medical Countermeasures Initiative (MCMi) grant #OCET 2021-1565 to S.K and intramural FDA-CBER COVID-19 supplemental funds.
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2022.103940