Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice

Diabetic neuropathy, which affects 7 to 9% of the world’s population and that is usually accompanied by anxiety and depression, is chronic pain that results from impaired function of the central or peripheral nervous system. This study aimed at evaluating the antihypernociceptive, antiallodynic, anx...

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Bibliographic Details
Published in:Advances in pharmacological and pharmaceutical sciences 2020-09, Vol.2020 (2020), p.1-14
Main Authors: Ben Besong, Egbe, Matah Marthe Mba, Vanessa, Atsamo, Albert Donatien, Yousseu Nana, William, Ateufack, Gilbert, Mbiantcha, Marius, Tsafack, Eric Gonzal, Djuichou Nguemnang, Stephanie Flore, Adjouzem, Carine Flore
Format: Article
Language:English
Subjects:
Acetaldehyde
Acids
Alcohol
Alcohol, Denatured
Analysis
Animals
Antianxiety agents
Antidepressants
Chronic pain
Depression, Mental
Diabetes
Diabetic neuropathies
Diabetic neuropathy
Drug dosages
Ethanol
Hyperglycemia
Pain
Pharmaceutical sciences
Pharmacology
Social aspects
Streptozocin
Tumor necrosis factor-TNF
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Summary:Diabetic neuropathy, which affects 7 to 9% of the world’s population and that is usually accompanied by anxiety and depression, is chronic pain that results from impaired function of the central or peripheral nervous system. This study aimed at evaluating the antihypernociceptive, antiallodynic, anxiolytic, and antidepressant effects of Dissotis thollonii extracts. Diabetic neuropathy was induced by intraperitoneal injection of streptozotocin (200 mg/kg) in mice. The aqueous and ethanol extracts (250 and 500 mg/kg) were administered orally. Hyperalgesia (thermal and chemical), allodynia (mechanical and thermal), anxiety (high plus labyrinth, light-dark box, and social interaction), and depression (open field test, suspension test tail, and forced swimming test) were evaluated, and then the levels of some cytokines and growth factors were determined. The aqueous and ethanol extracts of Dissotis thollonii demonstrated significant antihypernociceptive (inhibition of hyperalgesia and allodynia), anxiolytic, and antidepressant activities in mice made diabetic by STZ. The extracts also significantly inhibited (p
ISSN:2633-4682
2633-4690
2633-4690
DOI:10.1155/2020/8886894