The ameliorative effects of virgin olive oil and olive leaf extract on amikacin-induced nephrotoxicity in the rat

Amikacin is an important antibiotic, and its use is limited because of the induced nephrotoxicity. Thus, search for natural and synthetic agents that can moderate amikacin toxicity never stopped. The present study aims to investigate the possible ameliorative effects of virgin olive oil and olive le...

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Bibliographic Details
Published in:Toxicology reports 2015-01, Vol.2 (C), p.1327-1333
Main Authors: Abdel-Gayoum, Abdelgayoum A, Al-Hassan, Abdelrahman A, Ginawi, Ibrahim A, Alshankyty, Ibraheem M
Format: Article
Language:English
Subjects:
Amikacin
Nephrotoxicity
Olive leaf
Olive oil
Rat
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Summary:Amikacin is an important antibiotic, and its use is limited because of the induced nephrotoxicity. Thus, search for natural and synthetic agents that can moderate amikacin toxicity never stopped. The present study aims to investigate the possible ameliorative effects of virgin olive oil and olive leaf extract against the amikacin-induced nephrotoxicity in rat. 48 rats were distributed into 6 groups: 1-Animals of control (C) group were injected intraperitoneally (ip) with saline, 2-(AK); injected ip with amikacin {300 mg/kg/day for 12days}, 3-(OO) group: given olive oil {7 ml/kg/day for 16days}, 4-(OOAK) group: given olive oil as in OO and amikacin for 12days, 5-(OL) group: given olive leaf extract {50 mg/kg/day for 16days}, 6-(OLAK) group: given leaf extract as in OL and amikacin for 12days. Animals were fasted and sacrificed. Serum was used for biochemical analysis and kidneys for histopathology. Serum urea and creatinine were significantly (  
ISSN:2214-7500
2214-7500
DOI:10.1016/j.toxrep.2015.09.007