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Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. We conducted immunohistochemistry studies of inter...

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Bibliographic Details
Published in:Einstein (São Paulo, Brazil) Brazil), 2019-08, Vol.17 (4), p.eAO4637-eAO4637
Main Authors: Rodrigues, Luciano Miller Reis, Oliveira, Lilian Zerbinatti de, Silva, Mariane de Barros Ribeiro da, Accardo, Camila de Melo, Giglio, Adriana Braz Del, Pinhal, Maria Aparecida da Silva
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Language:English
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Summary:To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration patients, fracture patients, and healthy individuals. Interleukin 6 and cathepsin B seem to be related with physiopathology of intervertebral disc degeneration, since the levels of both were higher in discs of patients with intervertebral disc degeneration. Interleukin 6 and cathepsin B do not represent good biomarkers of degenerative intervertebral disc disease, since the level of such compounds is increased in the plasma of patients with fractures. Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.
ISSN:1679-4508
2317-6385
2317-6385
DOI:10.31744/einstein_journal/2019AO4637