Long-term outcomes in rapamycin on renal allograft function: a 30-year follow-up from a single-center experience

To evaluate long-term renal graft prognosis and the role of rapamycin from a single-center in China over a 30-year follow-up. This study enrolled a total of 654 patients who underwent kidney transplantation between 1989 and 2020. The basic characteristics of the included patients were collected. Gra...

Full description

Saved in:
Bibliographic Details
Published in:BMC nephrology 2024-09, Vol.25 (1), p.311-10, Article 311
Main Authors: Ji, Yisheng, Sun, Li, Fei, Shuang, Gao, Xiang, Chen, Hao, Han, Zhijian, Tao, Jun, Ju, Xiaobing, Wang, Zijie, Tan, Ruoyun, Gu, Min
Format: Article
Language:English
Subjects:
Adult
Albumen
Biopsy
Creatinine
Dialysis
Drug Therapy, Combination
Female
Follow-Up Studies
Globulins
Graft rejection
Graft Rejection - prevention & control
Graft Survival
Hemodialysis
Humans
Immunosuppression
Immunosuppressive agents
Immunosuppressive Agents - therapeutic use
Immunotherapy
Inflammation
Kidney diseases
Kidney Transplantation
Kidney transplants
Kidneys
Male
Medical prognosis
Middle Aged
Mortality
Patient outcomes
Patients
Peritoneal dialysis
Prediction model
Prognosis
Proportional Hazards Models
Rapamycin
Renal function
Retrospective Studies
Risk factors
Sirolimus - therapeutic use
Surgery
Survival
Tacrolimus
Tacrolimus - therapeutic use
Time Factors
Transplantation
Variance analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate long-term renal graft prognosis and the role of rapamycin from a single-center in China over a 30-year follow-up. This study enrolled a total of 654 patients who underwent kidney transplantation between 1989 and 2020. The basic characteristics of the included patients were collected. Graft survival was described and compared using Kaplan-Meier curves (K-M curves). Both continuous and categorical variables were included in a multivariate Cox proportional-hazards model. Patients were divided into rapamycin-based quadruple immunosuppression regimen group (rapa group, n = 41) and conventional tacrolimus-based triple immunosuppression regimen group (control group, n = 218). The indication biopsy results of the two groups were further reviewed to compare the incidence of rejection, acute rejection, and banff score. The overall 5, 10, 15, 20-year graft survival rate of our center is 87.5%, 62.4%, 46.4% and 20.9%, respectively. The median survival time after surgery is 14 years. Multiple Cox regression analysis identified BMI (p = 0.035), dialysis type (p 
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-024-03730-8