NOD Signaling and Cell Death

Innate immune signaling and programmed cell death are intimately linked, and many signaling pathways can regulate and induce both, transcription of inflammatory mediators or autonomous cell death. The best-characterized examples for these dual outcomes are members of the TNF superfamily, the inflamm...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2019-10, Vol.7, p.208-208
Main Authors: Heim, Valentin J., Stafford, Che A., Nachbur, Ueli
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
cell signaling
inflammation
NOD2
RIPK2
ubiquitin
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Summary:Innate immune signaling and programmed cell death are intimately linked, and many signaling pathways can regulate and induce both, transcription of inflammatory mediators or autonomous cell death. The best-characterized examples for these dual outcomes are members of the TNF superfamily, the inflammasome receptors, and the toll-like receptors. Signaling via the intracellular peptidoglycan receptors NOD1 and NOD2, however, does not appear to follow this trend, despite involving signaling proteins, or proteins with domains that are linked to programmed cell death, such as RIP kinases, inhibitors of apoptosis (IAP) proteins or the CARD domains on NOD1/2. To better understand the connections between NOD signaling and cell death induction, we here review the latest findings on the molecular regulation of signaling downstream of the NOD receptors and explore the links between this immune signaling pathway and the regulation of cell death.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2019.00208