Effect of metabolically healthy obesity on the development of arterial stiffness: a prospective cohort study

Metabolically healthy obesity (MHO) has been reported to be associated with the development of vascular damage by the carotid intima-media thickness, but the relationship between metabolic health and obesity phenotypes and arterial stiffness is still unknown. Our hypothesized that different metaboli...

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Bibliographic Details
Published in:Nutrition & metabolism 2020-07, Vol.17 (1), p.50-50, Article 50
Main Authors: Yuan, Yue, Mu, Jian-Jun, Chu, Chao, Zheng, Wen-Ling, Wang, Yang, Hu, Jia-Wen, Ma, Qiong, Yan, Yu, Liao, Yue-Yuan, Chen, Chen
Format: Article
Language:English
Subjects:
Analysis
Ankle
Arterial stiffness
Blood pressure
Brachial-ankle pulse wave velocity
Cholesterol
Cohort analysis
Creatinine
Diabetes
Genotype & phenotype
Health risk assessment
Heart failure
Hypertension
Hypotheses
Isometric
Metabolically healthy obesity
Metabolism
Mortality
Obesity
Phenotypes
Studies
Urine
Wave propagation
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Summary:Metabolically healthy obesity (MHO) has been reported to be associated with the development of vascular damage by the carotid intima-media thickness, but the relationship between metabolic health and obesity phenotypes and arterial stiffness is still unknown. Our hypothesized that different metabolic health and obesity phenotypes might be associated with the development of arterial stiffness, and that subjects in MHO phenotype might not have increased risks of arterial stiffness compared with those in metabolically healthy nonobesity phenotype (MHNO), while metabolic unhealthy individuals might have increased risks of arterial stiffness. A prospective cohort of 2076 participants (aged 36-48 years) who were enrolled in the Hanzhong Adolescent Hypertension Cohort Study in 2017 was analyzed in a cross-sectional analysis. A subgroup of 202 participants from 2005 to 2017 was selected by an isometric sampling method and was included in the final longitudinal analysis. We identified four metabolic health and obesity phenotypes for both the cross-sectional and longitudinal analyses as follows: MHNO, metabolically unhealthy nonobesity (MUNO), MHO, and metabolically unhealthy obesity (MUO). In the cross-sectional analysis, individuals with the MHO phenotype had the lowest brachial-ankle pulse wave velocity (baPWV) levels of the four phenotypes (  
ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-020-00474-8