Prevalence and risk factors of keratoconus (including oxidative stress biomarkers) in a cohort study of Shiraz university of medical science employees in Iran

To determine the prevalence of keratoconus in Shiraz University of Medical Sciences Employees and the related risk factors including oxidative stress biomarkers. 2546 subjects' mean age ± SD, 40.35 ± 6.70 (46% male) were recruited. All participants underwent objective refraction using auto-refr...

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Bibliographic Details
Published in:BMC ophthalmology 2023-04, Vol.23 (1), p.188-188, Article 188
Main Authors: Mohaghegh, Sahar, Kangari, Haleh, Masoumi, Seyed Jalil, Bamdad, Shahram, Rahmani, Saeed, Abdi, Saeed, Fazil, Nagham, Shahbazi, Saeedeh
Format: Article
Language:English
Subjects:
Acuity
Age
Astigmatism
Biological markers
Biomarkers
Blood tests
BMI
Body mass index
Cholesterol
Cohort analysis
Cohort Studies
Cornea
Disease
Education
Employees
Family medical history
Female
Females
HDL
Humans
Hyperglycemia
Investigations
Iran - epidemiology
Keratoconus
Keratoconus - diagnosis
Keratoconus - epidemiology
Laboratories
LDL
Lipids
Lipoproteins
Low density lipoprotein
Low density lipoprotein cholesterols
Low density lipoproteins
Male
Metabolism
Microscopy
Ophthalmology
Oxidative stress
Pathogenesis
Population
Prevalence
Refraction
Regression analysis
Risk Factors
Serum levels
Statistical analysis
Triglycerides
Vision Disorders
Visual impairment
Workers
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Summary:To determine the prevalence of keratoconus in Shiraz University of Medical Sciences Employees and the related risk factors including oxidative stress biomarkers. 2546 subjects' mean age ± SD, 40.35 ± 6.70 (46% male) were recruited. All participants underwent objective refraction using auto-refractometer and retinoscopy, followed by subjective refraction, and bio-microscopy. Pentacam imaging was performed for the detected keratoconus patients. The prevalence of keratoconus and frequency of the visual impairment among keratoconus cases were evaluated. Potential risk factors of sex, age, family history of keratoconus, body mass index ≥ 30 kg/m , serum levels of glucose ≥ 100 mg/d, low-density-lipoprotein-cholesterol (LDL) ≥ 110 mg/dL, high-density-lipoprotein-cholesterol ≤ 40 mg/d, and triglycerides ≥ 150 mg/dL in the blood were evaluated. The prevalence of keratoconus at least in one eye was 0.98% (95% CI: 0.6- 1.4%). The best corrected visual acuity in the keratoconus group was 0.06 ± 0.1 and the rest of the population was 0.01 ± 0.07 logMAR (p 
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-023-02934-0