Risk Factors for Severe Erectile Dysfunction after Focal Therapy with High-Intensity Focused Ultrasound for Prostate Cancer

The present study aimed to analyze the effect of predisposing clinical factors for severe erectile dysfunction (ED) in patients treated with focal therapy using high-intensity focused ultrasound (HIFU) for localized prostate cancer (PC). Patients without severe ED (International Index of Erectile Fu...

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Bibliographic Details
Published in:Biomedicines 2022-11, Vol.10 (11), p.2876
Main Authors: Shoji, Sunao, Kuroda, Satoshi, Uemura, Kohei, Oda, Kazuya, Kano, Tatsuo, Ogawa, Takahiro, Umemoto, Tatsuya, Nakano, Mayura, Kawakami, Masayoshi, Nitta, Masahiro, Hasegawa, Masanori, Miyajima, Akira
Format: Article
Language:English
Subjects:
Biopsy
Calibration
Cardiovascular disease
Complications and side effects
Erectile dysfunction
focal therapy
high-intensity focused ultrasound
Impotence
localized prostate cancer
Magnetic resonance imaging
Patients
Prostate cancer
Regression analysis
Risk factors
sexual function
treated area
Ultrasonic imaging
Ultrasound
Variance analysis
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Summary:The present study aimed to analyze the effect of predisposing clinical factors for severe erectile dysfunction (ED) in patients treated with focal therapy using high-intensity focused ultrasound (HIFU) for localized prostate cancer (PC). Patients without severe ED (International Index of Erectile Function-5 [IIEF-5] score ≥ 8) before focal HIFU therapy were included. A total of 92 of the 240 patients met the inclusion criteria and were included. The rate of severe ED (IIEF-5 ≤ 7) was 36% 12 months after treatment. Multivariable logistic regression analysis showed that the pre-procedural lower IIEF-5 score (odds ratio [OR] 0.812, p = 0.005), the pre-procedural lower score of the sexual domain of the Expanded Prostate Cancer Index Composite (OR 0.960, p = 0.038), and the treatment of the edge of the peripheral zone (PZ) in proximity to the neurovascular bundle (NVB) [treated vs. untreated, OR 8.048, p = 0.028] were significant risk factors for severe ED at 12 months after treatment. In conclusion, pre-procedural lower erectile function and treatment of the part in proximity to the NVB were significant risk factors for severe ED after focal therapy.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10112876