The clinical features and prognosis of infective endocarditis in the elderly from 2007 to 2016 in a tertiary hospital in China

• Published in: BMC infectious diseases 2019-11, Vol.19 (1), p.937-937, Article 937
• Main Authors: Wu, Zhenzhu, Chen, Yi, Xiao, Tingting, Niu, Tianshui, Shi, Qingyi, Xiao, Yonghong
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anemia; China; Comorbidity; Elderly; Elderly patients; Endocarditis; Endocarditis, Bacterial - diagnosis; Endocarditis, Bacterial - microbiology; Endocarditis, Bacterial - mortality; Endocarditis, Bacterial - surgery; Female; Fever; Follow-Up Studies; Hospital Mortality; Hospitals, University; Humans; Infective endocarditis; Male; Methicillin; Middle Aged; Mortality; Older patients; Oral Hygiene; Pathogenic microorganisms; Prognosis; Retrospective Studies; Risk factors; Staphylococcal Infections - diagnosis; Staphylococcal Infections - microbiology; Staphylococcus - isolation & purification; Streptococcal Infections - diagnosis; Streptococcal Infections - microbiology; Streptococcus - isolation & purification; Surgery; Surgical treatment; Survival Rate; Tertiary Care Centers
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-019-4546-6

Infective endocarditis (IE) especially in the elderly is a serious disease, with a worse prognosis. A retrospective cohort study was conducted. A total of 405 patients with definite IE were divided into three groups: 205 patients under 50 years old, 141 patients between 50 and 64 years old and 59 patients over 65 years old. For older patients, clinical symptoms such as fever, anemia, and heart murmur were as common as the younger patients. IE in old patients had more frequent nosocomial origin (P = 0.007) and tended to be more frequent with bad oral hygiene (p = 0.008). The most frequent isolated pathogens in the old groups was streptococci and coagulase-negative staphylococci. The old patients had a lower operation rate (40.7% vs 58.9% vs 62.4%, P = 0.012) and higher in-hospital mortality (20.3% vs 10.6% vs 8.8%, P = 0.044) compared with the younger patients. Surgical treatment was a significant predictor of one-year mortality even after adjusting for the confounders (HR = 2.45, 95% CI 1.027-10.598, P = 0.009). The one-year survival rate was higher for older patients with surgical intervention than those without (95.8% vs 68.6%, P = 0.007). Older patients with IE presented with more comorbidities, bad oral hygiene, more nosocomial origin and a more severe prognosis than younger patients. Streptococci was the most frequent micro-organisms in this group. Surgery were underused in old patients and those with surgical treatment had better prognosis.