Wernicke Encephalopathy: A case report

IntroductionWe report a case of a 56-year old woman with a history of depressive disorder between 2012 and 2017 achieving full remission after treatment with antidepressants and anxiolytics. In the year 2021 was presented to the emergency department manifesting alteration of behavioral patterns, ata...

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Bibliographic Details
Published in:European psychiatry 2022-06, Vol.65 (S1), p.S453-S453
Main Authors: Jiménez Cabañas, M., Ruiz Guerrero, F., Bermejo Pastor, A., Mayor Sanabria, F., Fernández Fariña, M., Saiz González, M.D.
Format: Article
Language:English
Subjects:
Abstract
alcohol
Ataxia
Case reports
E-Poster Viewing
Korsakoff
thiamine
Vitamin B
Wernicke
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Summary:IntroductionWe report a case of a 56-year old woman with a history of depressive disorder between 2012 and 2017 achieving full remission after treatment with antidepressants and anxiolytics. In the year 2021 was presented to the emergency department manifesting alteration of behavioral patterns, ataxia, mental confusion and horizontal nystagmus. A chronic alcohol abuse was also discovered while interviewing. She also exhibited low mood, anterograde amnesia and confabulations that improved rapidly after following treatment with thiamine.ObjectivesReviewing clinical manifestations and treatment of Wernicke encephalopathy and the development of Korsakoff syndrome.MethodsWe systematically reviewed articles using PubMed.ResultsWernicke encephalopathy is a well-known complication of thiamine deficiency, mostly associated with alcohol use disorder. Classically, the syndrome comprises changes in mental status, gait ataxia and ophthalmoplegia. However, the full triad has been described in only 10-17 % of cases, which in our the case is report. After the diagnosis was established and was treated with thiamine, a rapid improvement in the patient´s clinical status was observed. Cognitive impairment was later identified, taking into account the possibility of a Korsakoff syndrome characterized by irreversible brain damage and subsequent loss of anterograde memory. In our patient, this specific diagnosis was dismissed due to the clinical improvement after thiamine treatment.ConclusionsIt is relevant to emphasize the importance of a precise diagnosis and treatment of patients with Wernicke Encephalopathy to avoid the development of a Korsakoff syndrome.DisclosureNo significant relationships.
ISSN:0924-9338
1778-3585
DOI:10.1192/j.eurpsy.2022.1149