Application of nano-hydroxyapatite matrix graft in inter-vertebral fusion therapy: a meta-analysis

Nano-hydroxyapatite and its composites(nHA) have been widely used as grafts in inter-vertebral fusion. However, the safety and efficacy of the graft in inter-vertebral fusion is controversial. This meta-analysis aimed at evaluating the safety and efficacy of nHA and non-hydroxyapatite grafts (noHA)...

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Bibliographic Details
Published in:BMC musculoskeletal disorders 2023-05, Vol.24 (1), p.427-427, Article 427
Main Authors: Zhang, Kui, Zhu, Yandong, Wang, Wenji
Format: Article
Language:English
Subjects:
Artificial bones
Bone graft
Bone grafts
Bone Transplantation
Bones
Clinical medicine
Durapatite
Humans
Hydroxyapatite
Inter-vertebral fusion
Meta-analysis
Methods
Musculoskeletal diseases
Nano-hydroxyapatite
Reading
Safety
Skin & tissue grafts
Spinal Fusion
Spine
Statistical analysis
Surgery
Treatment Outcome
Vertebrae
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Summary:Nano-hydroxyapatite and its composites(nHA) have been widely used as grafts in inter-vertebral fusion. However, the safety and efficacy of the graft in inter-vertebral fusion is controversial. This meta-analysis aimed at evaluating the safety and efficacy of nHA and non-hydroxyapatite grafts (noHA) (autologous bone, etc.) in inter-body fusion. A comprehensive search was performed in electronic database as follows: PubMed, EMBASE, the Cochrane Library, Web of Science, and China National Knowledge Internet (CNKI) from inception until October 2022. Clinical studies on the effect of nHA and noHA in spinal fusion were collected. Analysis of outcome indicators using RevMan 5.4 statistical software. The meta-analysis showed that the operation time of patients who underwent inter-body fusion with nHA grafts was less than that of patients who underwent noHA (p 
ISSN:1471-2474
1471-2474
DOI:10.1186/s12891-023-06405-x