Automatic and efficient MRI-US segmentations for improving intraoperative image fusion in image-guided neurosurgery

• Published in: NeuroImage clinical 2019-01, Vol.22, p.101766-101766, Article 101766
• Main Authors: Nitsch, J, Klein, J, Dammann, P, Wrede, K, Gembruch, O, Moltz, J H, Meine, H, Sure, U, Kikinis, R, Miller, D
• Format: Article
• Language: English
• Subjects: Brain - anatomy & histology; Brain - diagnostic imaging; Brain - pathology; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - surgery; Dura Mater - diagnostic imaging; Glioma - diagnostic imaging; Glioma - surgery; Humans; Intraoperative Neurophysiological Monitoring - methods; Magnetic Resonance Imaging - methods; Neuronavigation - methods; Neurosurgical Procedures - methods; Regular; Surgery, Computer-Assisted - methods; Ultrasonography, Doppler, Transcranial - methods
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2019.101766

Knowledge of the exact tumor location and structures at risk in its vicinity are crucial for neurosurgical interventions. Neuronavigation systems support navigation within the patient's brain, based on preoperative MRI (preMRI). However, increasing tissue deformation during the course of tumor resection reduces navigation accuracy based on preMRI. Intraoperative ultrasound (iUS) is therefore used as real-time intraoperative imaging. Registration of preMRI and iUS remains a challenge due to different or varying contrasts in iUS and preMRI. Here, we present an automatic and efficient segmentation of B-mode US images to support the registration process. The falx cerebri and the tentorium cerebelli were identified as examples for central cerebral structures and their segmentations can serve as guiding frame for multi-modal image registration. Segmentations of the falx and tentorium were performed with an average Dice coefficient of 0.74 and an average Hausdorff distance of 12.2 mm. The subsequent registration incorporates these segmentations and increases accuracy, robustness and speed of the overall registration process compared to purely intensity-based registration. For validation an expert manually located corresponding landmarks. Our approach reduces the initial mean Target Registration Error from 16.9 mm to 3.8 mm using our intensity-based registration and to 2.2 mm with our combined segmentation and registration approach. The intensity-based registration reduced the maximum initial TRE from 19.4 mm to 5.6 mm, with the approach incorporating segmentations this is reduced to 3.0 mm. Mean volumetric intensity-based registration of preMRI and iUS took 40.5 s, including segmentations 12.0 s.