A fast and highly efficient one-pot synthesis of novel isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement using task-specific ionic liquid [HMIm]BF4 as green solvent

A facile and convenient procedure for the synthesis of isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement from isoxazole amine, chloroacetyl chloride and 2-chloro-3-hydroxypyridine using [HMIm]BF 4 as task-specific ionic liquid has been described. The protocol proves to be effic...

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Bibliographic Details
Published in:Green chemistry letters and reviews 2017-01, Vol.10 (1), p.48-53
Main Authors: Reddy, Modugu Nagi, Kumar, Pittala Praveen, Rajanarendar, Eligeti
Format: Article
Language:English
Subjects:
Green chemistry
ionic liquid
Ions
Isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones
Smiles rearrangement
Solvents
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Summary:A facile and convenient procedure for the synthesis of isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement from isoxazole amine, chloroacetyl chloride and 2-chloro-3-hydroxypyridine using [HMIm]BF 4 as task-specific ionic liquid has been described. The protocol proves to be efficient and environmentally benign in terms of high yields, eco-friendly solvent, ease of recovery, and reusability of reaction medium.
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2017.1285966