Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke

• Published in: Neural regeneration research 2017-03, Vol.12 (3), p.341-350
• Main Authors: Lee, Jin Hwan, Zhang, James, Yu, Shan Ping
• Format: Article
• Language: English
• Subjects: Apoptosis; Brain damage; Brain research; Care and treatment; Clinical medicine; Cytochrome; Drug therapy; Free radicals; Genetic aspects; Health aspects; Hypothermia; Invited Review; Ischemia; Metabolism; Oxidative stress; Proteins; Stroke; stroke; therapeutic hypothermia; drug-induced hypothermia; ischemia; cell death; inflammation; Tissue plasminogen activator; Traumatic brain injury; Tumor necrosis factor-TNF; 中枢神经系统损伤; 中风; 临床治疗; 亚低温; 保护机制; 组织型纤溶酶原激活剂; 缺血; 转化
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.202915

Stroke is a leading cause of disability and death,yet effective treatments for acute stroke has been very limited.Thus far,tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients,yet its application is only applicable to less than 4–5% of stroke patients due to the narrow therapeutic window（〈 4.5 hours after the onset of stroke） and the high risk of hemorrhagic transformation.Emerging evidence from basic and clinical studies has shown that therapeutic hypothermia,also known as targeted temperature management,can be a promising therapy for patients with different types of stroke.Moreover,the success in animal models using pharmacologically induced hypothermia（PIH） has gained increasing momentum for clinical translation of hypothermic therapy.This review provides an updated overview of the mechanisms and protective effects of therapeutic hypothermia,as well as the recent development and findings behind PIH treatment.It is expected that a safe and effective hypothermic therapy has a high translational potential for clinical treatment of patients with stroke and other CNS injuries.