A Delphi Consensus Document on the Use of Single-Inhaler Fixed-Dose Triple Therapies in COPD Patients

Despite the evidence provided by clinical trials, there are some uncertainties and controversies regarding the use of triple inhaled therapy. With the aim of evaluating clinical practice in specialized respiratory units, a Delphi consensus document was implemented on the use of single-inhaler fixed-...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2020-01, Vol.15, p.1801-1811
Main Authors: López-Campos, José Luis, Alcázar Navarrete, Bernardino, Riesco Miranda, Juan Antonio, Cosío, Borja G, de-Torres, Juan P, Celli, Bartolomé, Jiménez-Ruiz, Carlos A, Casanova Macario, Ciro
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adrenal Cortex Hormones - adverse effects
Adrenergic beta-2 Receptor Agonists - therapeutic use
bronchodilator agents
Bronchodilator Agents - adverse effects
Care and treatment
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
Clinical trials
Consensus
delphi consensus
Delphi method
Dosage and administration
Drug Combinations
Drug dosages
Humans
inhaled corticosteroids
Inhalers
laba/ics
laba/lama
Likert scale
Muscarinic Antagonists - adverse effects
Nebulizers and Vaporizers
Original Research
Pharmaceutical industry
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - drug therapy
Questionnaires
Spain
statements
Systematic review
Tiotropium
triple therapy
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Summary:Despite the evidence provided by clinical trials, there are some uncertainties and controversies regarding the use of triple inhaled therapy. With the aim of evaluating clinical practice in specialized respiratory units, a Delphi consensus document was implemented on the use of single-inhaler fixed-dose triple therapies after 1 year of use in Spain. A scientific committee of COPD experts defined a thematic index, guided a systematic literature review and helped design the Delphi questionnaire. This was sent to the other 45 COPD experts between April and June 2019. Agreement/disagreement on 58 statements was tested in two rounds using a Likert scale. Replies were classified as a consensus when ≥80% of the panelists agreed; a majority when a degree of agreement of ≥66% was reached; and divergence if agreement was
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S258818