Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma

Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these prote...

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Zhu, Qing, Ying, Xia, Wang, Li-juan, Guo, Xi-jing, He, Chen-chen, Jin, Gui-hua, Bai, E., Han, Su-xia, Li, Meng
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
alpha-Fetoproteins - genetics
Amphiregulin
Apoptosis
Biomarkers, Tumor - genetics
Breast cancer
Cancer therapies
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Cell Cycle Proteins
Cell growth
Colleges & universities
EGF Family of Proteins - genetics
Epidermal growth factor
Female
Gene Expression Regulation, Neoplastic
Hospitals
Humans
Immunology
Liver cancer
Liver Neoplasms - diagnosis
Liver Neoplasms - genetics
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Maternal & child health
Medical prognosis
Middle Aged
Neoplasm Staging
Nuclear Proteins - genetics
Prognosis
Proteins
Rodents
Survival Analysis
Transcription Factors - genetics
Tumorigenesis
Tumors
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Summary:Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage ( P > 0 . 05 ), serum AFP level ( P > 0 . 05 ), and HCC prognosis ( P > 0 . 05 ). AREG expression was also significantly correlated with Edmondson stage ( P > 0 . 05 ) and serum AFP level ( P > 0 . 05 ). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC.
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/261365