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Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these prote...
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| Published in: | Journal of immunology research 2014-01, Vol.2014 (2014), p.1-10 |
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| creator | Zhu, Qing Ying, Xia Wang, Li-juan Guo, Xi-jing He, Chen-chen Jin, Gui-hua Bai, E. Han, Su-xia Li, Meng |
| description | Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage ( P > 0 . 05 ), serum AFP level ( P > 0 . 05 ), and HCC prognosis ( P > 0 . 05 ). AREG expression was also significantly correlated with Edmondson stage ( P > 0 . 05 ) and serum AFP level ( P > 0 . 05 ). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC. |
| doi_str_mv | 10.1155/2014/261365 |
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Martin</contributor><creatorcontrib>Zhu, Qing ; Ying, Xia ; Wang, Li-juan ; Guo, Xi-jing ; He, Chen-chen ; Jin, Gui-hua ; Bai, E. ; Han, Su-xia ; Li, Meng ; Kast, W. Martin</creatorcontrib><description>Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage ( P > 0 . 05 ), serum AFP level ( P > 0 . 05 ), and HCC prognosis ( P > 0 . 05 ). AREG expression was also significantly correlated with Edmondson stage ( P > 0 . 05 ) and serum AFP level ( P > 0 . 05 ). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC.</description><identifier>ISSN: 2314-8861</identifier><identifier>EISSN: 2314-7156</identifier><identifier>DOI: 10.1155/2014/261365</identifier><identifier>PMID: 24860833</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Adult ; Aged ; alpha-Fetoproteins - genetics ; Amphiregulin ; Apoptosis ; Biomarkers, Tumor - genetics ; Breast cancer ; Cancer therapies ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Cell Cycle Proteins ; Cell growth ; Colleges & universities ; EGF Family of Proteins - genetics ; Epidermal growth factor ; Female ; Gene Expression Regulation, Neoplastic ; Hospitals ; Humans ; Immunology ; Liver cancer ; Liver Neoplasms - diagnosis ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Male ; Maternal & child health ; Medical prognosis ; Middle Aged ; Neoplasm Staging ; Nuclear Proteins - genetics ; Prognosis ; Proteins ; Rodents ; Survival Analysis ; Transcription Factors - genetics ; Tumorigenesis ; Tumors</subject><ispartof>Journal of immunology research, 2014-01, Vol.2014 (2014), p.1-10</ispartof><rights>Copyright © 2014 Su-xia Han et al.</rights><rights>Copyright © 2014 Su-xia Han et al. Su-xia Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Su-xia Han et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-b65d301ee0cd813a6ebce268e0a80a321075316ca06a9316eeac29b0257c79863</citedby><cites>FETCH-LOGICAL-c730t-b65d301ee0cd813a6ebce268e0a80a321075316ca06a9316eeac29b0257c79863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1546440644/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1546440644?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24860833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kast, W. Martin</contributor><creatorcontrib>Zhu, Qing</creatorcontrib><creatorcontrib>Ying, Xia</creatorcontrib><creatorcontrib>Wang, Li-juan</creatorcontrib><creatorcontrib>Guo, Xi-jing</creatorcontrib><creatorcontrib>He, Chen-chen</creatorcontrib><creatorcontrib>Jin, Gui-hua</creatorcontrib><creatorcontrib>Bai, E.</creatorcontrib><creatorcontrib>Han, Su-xia</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><title>Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma</title><title>Journal of immunology research</title><addtitle>J Immunol Res</addtitle><description>Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage ( P > 0 . 05 ), serum AFP level ( P > 0 . 05 ), and HCC prognosis ( P > 0 . 05 ). AREG expression was also significantly correlated with Edmondson stage ( P > 0 . 05 ) and serum AFP level ( P > 0 . 05 ). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>alpha-Fetoproteins - genetics</subject><subject>Amphiregulin</subject><subject>Apoptosis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Cycle Proteins</subject><subject>Cell growth</subject><subject>Colleges & universities</subject><subject>EGF Family of Proteins - genetics</subject><subject>Epidermal growth factor</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - 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Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma</atitle><jtitle>Journal of immunology research</jtitle><addtitle>J Immunol Res</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2314-8861</issn><eissn>2314-7156</eissn><abstract>Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage ( P > 0 . 05 ), serum AFP level ( P > 0 . 05 ), and HCC prognosis ( P > 0 . 05 ). AREG expression was also significantly correlated with Edmondson stage ( P > 0 . 05 ) and serum AFP level ( P > 0 . 05 ). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24860833</pmid><doi>10.1155/2014/261365</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged alpha-Fetoproteins - genetics Amphiregulin Apoptosis Biomarkers, Tumor - genetics Breast cancer Cancer therapies Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Cycle Proteins Cell growth Colleges & universities EGF Family of Proteins - genetics Epidermal growth factor Female Gene Expression Regulation, Neoplastic Hospitals Humans Immunology Liver cancer Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Male Maternal & child health Medical prognosis Middle Aged Neoplasm Staging Nuclear Proteins - genetics Prognosis Proteins Rodents Survival Analysis Transcription Factors - genetics Tumorigenesis Tumors |
| title | Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
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