Synthetic cell division via membrane-transforming molecular assemblies

Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell division machinery. In this review, we will il...

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Bibliographic Details
Published in:BMC biology 2019-05, Vol.17 (1), p.43-43, Article 43
Main Authors: Kretschmer, Simon, Ganzinger, Kristina A, Franquelim, Henri G, Schwille, Petra
Format: Article
Language:English
Subjects:
Artificial Cells
Bacterial Physiological Phenomena
Biological research
Biophysics
Bottom-up synthetic biology
Cell Division
Cell membranes
Deoxyribonucleic acid
Design
DNA
FtsZ
In vitro reconstitution
Lipids
Membranes
Methods
Microscopy
MinCDE
Minimal cell
Model membrane systems
Peptides
Proteins
Reproduction
Review
Structure
Synthetic biology
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Summary:Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell division machinery. In this review, we will illustrate how nature solves this task, describing membrane remodelling processes in general and focusing on bacterial cell division in particular. We discuss recent progress made in their in vitro reconstitution, identify open challenges, and suggest how purely synthetic building blocks could provide an additional and attractive route to creating artificial cell division machineries.
ISSN:1741-7007
1741-7007
DOI:10.1186/s12915-019-0665-1