Non-Hodgkin Lymphoma of the Stomach in a Patient Treated with Natalizumab

A 61-year-old man with relapsing-remitting multiple sclerosis developed extranodal large B-cell lymphoma of the stomach following monthly natalizumab infusions for 6 years. Development of lymphoproliferative disorders increases with chronic use of immunosuppression. Cases of primary central nervous...

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Bibliographic Details
Published in:Clinical Medicine Insights. Oncology 2015-01, Vol.9
Main Authors: Jennie Y. Law, Dong W. Kim, Ariel Sturgis, Harris V. Naina
Format: Article
Language:English
Online Access:Get full text
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Summary:A 61-year-old man with relapsing-remitting multiple sclerosis developed extranodal large B-cell lymphoma of the stomach following monthly natalizumab infusions for 6 years. Development of lymphoproliferative disorders increases with chronic use of immunosuppression. Cases of primary central nervous system lymphoma as well as one case of peripheral T-cell lymphoma have previously been reported with natalizumab use. Given the absence of a known association between multiple sclerosis and extranodal presentations of diffuse large B-cell lymphoma, a causal association with natalizumab administration cannot be excluded.
ISSN:1179-5549
DOI:10.4137/CMO.S27142