HTLV-I associated myelopathy in patients from Brazil and Iran: neurological manifestations and cerebrospinal fluid findings

We analysed sera and cerebrospinal fluid (CSF) of 20 cases of human T-cell lymphotropic virus type (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) from Brazil and Iran and as controls, 16 Brazilian HTLVI seronegative individuals afflicted with other neurological diseases. It wa...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 1995-06, Vol.53 (2), p.213-217
Main Authors: Puccioni-Sohler, M, Kitze, B, Felgenhauer, K
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Brazil
esclerose múltipla
Female
HAM
HTLV-I
HTLV-I Antibodies - cerebrospinal fluid
Humans
Immunoglobulin G - cerebrospinal fluid
Iran
líquido cefalorraquidiano
Male
Middle Aged
mielopatia
NEUROSCIENCES
Paraparesis, Tropical Spastic - cerebrospinal fluid
PSYCHIATRY
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Summary:We analysed sera and cerebrospinal fluid (CSF) of 20 cases of human T-cell lymphotropic virus type (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) from Brazil and Iran and as controls, 16 Brazilian HTLVI seronegative individuals afflicted with other neurological diseases. It was observed in the HAM/TSP patients that: 1) all had an inflammatory reaction within the central nervous system (CNS); 2) 95% (19/20) showed oligoclonal bands reflecting intrathecal IgG synthesis; 3) 85% (17/20) presented a local synthesis of HTLVI antibodies; 4) 35% (7/20) had a measurable immunoglobulin (Ig) synthesis within the CNS. The CSF parameters of the HAM/TSP were compared with the clinical data (age at onset, duration of disease and disability level). Our data prove that CSF analysis is important for the diagnosis of HAM/TSP. There is no association between the severity of the disease and CSF findings.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/s0004-282x1995000200005