A Smart Core-Crosslinked Supramolecular Drug Delivery System (SDDS) Enabled by Pendant Cyclodextrins Encapsulation of Drug Dimers via Host-Guest Interaction

Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD)...

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Bibliographic Details
Published in:Biosensors (Basel) 2021-08, Vol.11 (9), p.306
Main Authors: Xing, Xin, Guo, Zhijun, Su, Yue, Yang, Zhen, Qian, Jiwen, Tu, Chunlai, Zhu, Lijuan, Xu, Feng
Format: Article
Language:English
Subjects:
Alkynes
Anticancer properties
Cancer
Chemical bonds
Chemical synthesis
Chemotherapy
Chromatography
core-crosslinked micelles
Crosslinking
Cyclodextrin
cyclodextrin-based polymer
Cyclodextrins
Cytotoxicity
Dapsone - analogs & derivatives
Dimers
Disulfide bonds
Disulfides
Dithiothreitol
Drug delivery
Drug Delivery Systems
drug dimer
Efficiency
Micelles
Molecular weight
Morphology
NMR
Nuclear magnetic resonance
Polyethylene glycol
Polymerization
Polymers
Ring opening polymerization
Sensors
Stimuli
stimuli-responsive
supramolecular drug delivery system
Toxicity
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Summary:Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD) which crosslinked by stimuli-cleavable drug dimers via host-guest interaction. PEGylated PCD was precisely controlled synthesized by ring-opening polymerization and azide-alkyne click chemistry, and two doxorubicins (DOX) were linked with a disulfide bond to form a drug dimer (ss-DOX). They then co-assembled into supramolecular micelles. Drug dimers were utilized as cross-linkers to stabilize the micelles. The drug loading efficiency was very high that could be up to 98%. The size and morphology were measured by DLS and TEM. Owing to the disulfide bonds of drug dimers, these supramolecular micelles were dissociated by treating with dithiothreitol (DTT). In the meanwhile, the free DOXs were recovered and released from cavities of cyclodextrins because of dynamic equilibrium and hydrophilicity changes. The release profile was studied under mimic physiological conditions. Furthermore, in vitro cytotoxicity study showed excellent anti-cancer efficacy of reduced-responsive supramolecular polymeric micelles. Therefore, it can be served as a safe and stimuli-responsive SDDS for cancer therapy.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios11090306