Advanced Nanomaterials-Based Electrochemical Biosensors for Catecholamines Detection: Challenges and Trends

Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups of neurotransmitters in the central nervous system (CNS), in which they act at the brain's highest levels of mental function and play key roles in neurological disorders. Accord...

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Bibliographic Details
Published in:Biosensors (Basel) 2023-01, Vol.13 (2), p.211
Main Authors: Fredj, Zina, Sawan, Mohamad
Format: Article
Language:English
Subjects:
Biological properties
Biological samples
Biosensing Techniques
Biosensors
Brain diseases
Brain research
Carbon
Catecholamine
catecholamine neurotransmitters
Catecholamines
Central nervous system
Coronaviruses
COVID-19
Disease transmission
Dopamine
Electrochemical apparatus
electrochemical biosensor
Electrochemical Techniques
Electrochemistry
Epilepsy
Epinephrine
Health aspects
Medical diagnosis
Mental disorders
Nanomaterials
Nanostructures
Nanotechnology
Nervous system
Neurological diseases
Neurotransmitter Agents
Neurotransmitters
Norepinephrine
Performance measurement
Physiological aspects
Physiology
R&D
Research & development
Review
Sensors
Subgroups
Trends
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Summary:Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups of neurotransmitters in the central nervous system (CNS), in which they act at the brain's highest levels of mental function and play key roles in neurological disorders. Accordingly, the analysis of such catecholamines in biological samples has shown a great interest in clinical and pharmaceutical importance toward the early diagnosis of neurological diseases such as Epilepsy, Parkinson, and Alzheimer diseases. As promising routes for the real-time monitoring of catecholamine neurotransmitters, optical and electrochemical biosensors have been widely adopted and perceived as a dramatically accelerating development in the last decade. Therefore, this review aims to provide a comprehensive overview on the recent advances and main challenges in catecholamines biosensors. Particular emphasis is given to electrochemical biosensors, reviewing their sensing mechanism and the unique characteristics brought by the emergence of nanotechnology. Based on specific biosensors' performance metrics, multiple perspectives on the therapeutic use of nanomaterial for catecholamines analysis and future development trends are also summarized.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios13020211