Accuracy of intraoperative frozen section in surgical staging of endometrial cancer

This study evaluates the role of frozen section (FS) in determining the extent of disease during surgery. This study retrospectively analyzed a cohort of patients diagnosed with endometrioid-type endometrial cancer between 2019 and 2022 who underwent surgical intervention. The frozen section (FS) re...

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Bibliographic Details
Published in:Heliyon 2024-10, Vol.10 (19), p.e39027, Article e39027
Main Authors: Gokulu, Sevki G., Ilhan, Tolgay T., Ulger, Gorkem, Yildizbakan, Ali, Cevikoglu-Killi, Murside, Turkmen, Ayse
Format: Article
Language:English
Subjects:
Endometrial cancer
endometrium
Frozen sections
histology
morbidity
Paraffin sections
risk
surgery
Surgical staging
uterine neoplasms
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Summary:This study evaluates the role of frozen section (FS) in determining the extent of disease during surgery. This study retrospectively analyzed a cohort of patients diagnosed with endometrioid-type endometrial cancer between 2019 and 2022 who underwent surgical intervention. The frozen section (FS) results were compared with the final pathology reports, focusing on tumor grade, depth of myometrial invasion, cervical involvement, and tumor diameter. The final analysis included 187 patients. The predictive accuracy of FS in determining PS results was 85.6 % for endometrioid histology, 95.7 % for grade 3 tumors, 90.2 % for depth of myometrial invasion, 89.7 % for cervical involvement, and 95.9 % for tumor diameter. Notably, 9.8 % of cases initially classified as grade 1 intraoperatively were upgraded with the final pathology. Similarly, 6.3 % of grade II cases were upgraded, while 60.4 % were downgraded. Our study highlights the effectiveness of FS as a dependable tool for assessing endometrial carcinomas and guiding surgical staging decisions. By utilizing FS, the risk of unnecessary surgeries and associated morbidity in patients can be reduced.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e39027