Plasma PLTP activity is inversely associated with HDL-C levels

Phospholipid transfer protein (PLTP) is an important modulator of lipoprotein metabolism, including interparticle phospholipid transfer, remodeling of HDL, cholesterol and phospholipid efflux from peripheral tissues, and the production of hepatic VLDL. PLTP also plays an important role in inflammati...

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Bibliographic Details
Published in:Nutrition & metabolism 2009-11, Vol.6 (1), p.49-49, Article 49
Main Authors: Chen, Xueying, Sun, Aijun, Mansoor, Ather, Zou, Yunzeng, Ge, Junbo, Lazar, Jason M, Jiang, Xian-Cheng
Format: Article
Language:English
Subjects:
Cardiovascular disease
Carrier proteins
Cholesterol
High density lipoproteins
Lipid metabolism
Physiological aspects
Plasma
Studies
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Summary:Phospholipid transfer protein (PLTP) is an important modulator of lipoprotein metabolism, including interparticle phospholipid transfer, remodeling of HDL, cholesterol and phospholipid efflux from peripheral tissues, and the production of hepatic VLDL. PLTP also plays an important role in inflammation and oxidative stress. Accordingly, PLTP has been implicated in the development of atherosclerosis. In this study, we evaluated the association between PLTP activity and lipoprotein metabolism in a Chinese patients cohort with or without coronary heart disease (CHD group n = 407, control group n = 215), the PLTP activity was measured and PLTP genotyping was screened for sequence anomalies by PCR. We found that human plasma PLTP activity was negatively associated with plasma HDL and apoA-I levels, and positively associated with plasma TG, apoB and apoE levels. We also found that PLTP rs2294213 polymorphism was tended to be associated with increased plasma PLTP activity.
ISSN:1743-7075
1743-7075
DOI:10.1186/1743-7075-6-49