Clinical Outcomes of Enamel Matrix Derivate Used in Surgical and Non-Surgical Treatment of Peri-Implantitis: A Systematic Review of Clinical Studies

: The aim of this systematic review was to assess the available evidence of using enamel matrix derivate in the treatment of peri-implantitis. : Three electronic databases ( , , and ) were searched until August 2022 to identify relevant articles. The inclusion criteria consisted in human clinical st...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2022-12, Vol.58 (12), p.1819
Main Authors: Moldovan, Raluca, Mester, Alexandru, Piciu, Andra, Bran, Simion, Onisor, Florin
Format: Article
Language:English
Subjects:
Bias
Biofilms
Care and treatment
Clinical trials
Cohort analysis
Debridement
Dental implants
Diagnosis
Disease
Enamel
enamel matrix derivate
Health aspects
Humans
Implant dentures
Inflammation
Mucositis
non-surgical treatment
Patients
peri-implant disease
peri-implantitis
Peri-Implantitis - drug therapy
Peri-Implantitis - surgery
Prostheses
Research Design
Risk factors
Skin & tissue grafts
Statistical analysis
surgical treatment
Systematic Review
Tissue engineering
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Summary:: The aim of this systematic review was to assess the available evidence of using enamel matrix derivate in the treatment of peri-implantitis. : Three electronic databases ( , , and ) were searched until August 2022 to identify relevant articles. The inclusion criteria consisted in human clinical studies that reported the use of enamel matrix derivate (EMD) in surgical and non-surgical treatment of peri-implantitis. The risk of bias was assessed using Cochrane risk of bias tool for randomized clinical trials (RCTs) and for non-RCTs ROBINS-I tool. : Clinical studies included were published between 2012 and 2022 and consisted of two randomized clinical trials (RCTs) for non-surgical therapy and two RCTs, three prospective cohort studies, and one retrospective case series in surgical therapy. Due to the heterogeneity of patients' characteristics and assessment of peri-implant therapy, statistical analysis could not be achieved. : The use of EMD indicated a positive effect on both surgical and non-surgical therapy. However, the available literature is scarce, with low evidence in non-surgical approach and modest evidence in surgical approach using EMD. More RCTs with standardize protocols are necessary to evaluate the efficacy of using EMD in both therapies.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina58121819