Potential utility of hemogram indices in hepatitis C virus-related vasculitis: a case–control study

Background Hemogram indices are simple, economic indicators of the systemic inflammation characteristic of autoimmune diseases including vasculitides. The clinical utility of hemogram indices in hepatitis C virus-related vasculitis (HCV-V) has not been established. This study aimed to evaluate neutr...

Full description

Saved in:
Bibliographic Details
Published in:The Egyptian journal of internal medicine 2024-07, Vol.36 (1), p.75-7, Article 75
Main Authors: Abdulazim, Dina O., Fawzy, Samar M., El-Hindawy, Aya K., Abdelaziz, Mohamed S., Eissa, Basma M.
Format: Article
Language:English
Subjects:
Arthritis
Biomarkers
Blood
Blood platelets
Chronic illnesses
Disease
Gangrene
HCV
Hemoglobin
Hepatitis C
Infections
Inflammation
Internal Medicine
Leukocytes
Lymphocytes
Medical research
Medicine
Medicine & Public Health
Nervous system
Neutrophil to lymphocyte ratio
Neutrophils
Peripheral neuropathy
Platelet to lymphocyte ratio
Purpura
Regression analysis
Ribonucleic acid
RNA
Systemic immune inflammation index
Ulcers
Vasculitis
Viral infections
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Hemogram indices are simple, economic indicators of the systemic inflammation characteristic of autoimmune diseases including vasculitides. The clinical utility of hemogram indices in hepatitis C virus-related vasculitis (HCV-V) has not been established. This study aimed to evaluate neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), neutrophil/hemoglobin ratio (NHR), platelet/hemoglobin ratio (PHR), and systemic immune-inflammation index (SII) as potential biomarkers of HCV-V, and their relationship with disease activity. This cross-sectional case–control study was conducted in the departments of Rheumatology and Rehabilitation and Hepatogastroenterology, at Cairo University Hospital. Patients with HCV-V, patients with HCV infection free from extrahepatic manifestations (HCV sine vasculitis), and healthy control subjects were recruited. HCV-V activity was assessed using the Birmingham Vasculitis Activity Score (BVAS). Results Twenty-four HCV-V patients, 21 HCV sine vasculitis patients, and 40 healthy controls were recruited. Age and sex distribution was similar across groups. In HCV-V patients, NLR, PLR, NHR, and SII were higher than healthy controls, with NLR (area under curve (AUC) 0.94, p  = 0.002), PLR (AUC 0.72, p  = 0.007), NHR (AUC 0.89, p  
ISSN:2090-9098
1110-7782
2090-9098
DOI:10.1186/s43162-024-00344-2