C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration

• Published in: Frontiers in immunology 2024-04, Vol.15, p.1330913-1330913
• Main Authors: Giralt, Lena, Figueras-Roca, Marc, Eguileor, Beatriz De Luis, Romero, Barbara, Zarranz-Ventura, Javier, Alforja, Socorro, Santiago, Francisca, Bolaños, Jennifer, Lozano, Francisco, Dotti-Boada, Marina, Sala-Puigdollers, Anna, Dura, Paula, Izquierdo-Serra, Jordi, Valero, Oliver, Adan, Alfredo, Fonollosa, Alex, Molins, Blanca
• Format: Article
• Language: English
• Subjects: age-related macular degeneration; biomarker; C-reactive protein; complement factor H; Immunology; inflammation; retina
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2024.1330913

To determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters. Cross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters. Patients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels