The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy

• Published in: Frontiers in cardiovascular medicine 2023-12, Vol.10, p.1301509-1301509
• Main Authors: Kan, Ao, Leng, Yinping, Li, Shuhao, Lin, Fang, Fang, Qimin, Tao, Xinwei, Hu, Mengyao, Gong, Lianggeng
• Format: Article
• Language: English
• Subjects: cardiac magnetic resonance; Cardiovascular Medicine; coronary microvascular dysfunction; dilated cardiomyopathy; left ventricular reverse remodelling; myocardial perfusion
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2023.1301509

To evaluate the degree of coronary microvascular dysfunction (CMD) in dilated cardiomyopathy (DCM) patients by cardiac magnetic resonance (CMR) first-pass perfusion parameters and to examine the correlation between myocardial perfusion and left ventricle reverse remodelling (LVRR). In this study, 94 DCM patients and 35 healthy controls matched for age and sex were included. Myocardial perfusion parameters, including upslope, time to maximum signal intensity (Time ), maximum signal intensity (SI ), baseline signal intensity (SI ), and the difference between maximum and baseline signal intensity (SI ) were measured. Additionally, left ventricular (LV) structure, function parameters, and late gadolinium enhancement (LGE) were also recorded. The parameters were compared between healthy controls and DCM patients. Univariable and multivariable logistic regression analyses were used to determine the predictors of LVRR. With a median follow-up period of 12 months [interquartile range (IQR), 8-13], 41 DCM patients (44%) achieved LVRR. Compared with healthy controls, DCM patients presented CMD with reduced upslope, SI , and increased Time (all