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Deep learning assisted diagnosis system: improving the diagnostic accuracy of distal radius fractures

ObjectivesTo explore an intelligent detection technology based on deep learning algorithms to assist the clinical diagnosis of distal radius fractures (DRFs), and further compare it with human performance to verify the feasibility of this method. MethodsA total of 3,240 patients (fracture: n = 1,620...

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Published in:Frontiers in medicine 2023-08, Vol.10, p.1224489-1224489
Main Authors: Zhang, Jiayao, Li, Zhimin, Lin, Heng, Xue, Mingdi, Wang, Honglin, Fang, Ying, Liu, Songxiang, Huo, Tongtong, Zhou, Hong, Yang, Jiaming, Xie, Yi, Xie, Mao, Lu, Lin, Liu, Pengran, Ye, Zhewei
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container_title Frontiers in medicine
container_volume 10
creator Zhang, Jiayao
Li, Zhimin
Lin, Heng
Xue, Mingdi
Wang, Honglin
Fang, Ying
Liu, Songxiang
Huo, Tongtong
Zhou, Hong
Yang, Jiaming
Xie, Yi
Xie, Mao
Lu, Lin
Liu, Pengran
Ye, Zhewei
description ObjectivesTo explore an intelligent detection technology based on deep learning algorithms to assist the clinical diagnosis of distal radius fractures (DRFs), and further compare it with human performance to verify the feasibility of this method. MethodsA total of 3,240 patients (fracture: n = 1,620, normal: n = 1,620) were included in this study, with a total of 3,276 wrist joint anteroposterior (AP) X-ray films (1,639 fractured, 1,637 normal) and 3,260 wrist joint lateral X-ray films (1,623 fractured, 1,637 normal). We divided the patients into training set, validation set and test set in a ratio of 7:1.5:1.5. The deep learning models were developed using the data from the training and validation sets, and then their effectiveness were evaluated using the data from the test set. Evaluate the diagnostic performance of deep learning models using receiver operating characteristic (ROC) curves and area under the curve (AUC), accuracy, sensitivity, and specificity, and compare them with medical professionals. ResultsThe deep learning ensemble model had excellent accuracy (97.03%), sensitivity (95.70%), and specificity (98.37%) in detecting DRFs. Among them, the accuracy of the AP view was 97.75%, the sensitivity 97.13%, and the specificity 98.37%; the accuracy of the lateral view was 96.32%, the sensitivity 94.26%, and the specificity 98.37%. When the wrist joint is counted, the accuracy was 97.55%, the sensitivity 98.36%, and the specificity 96.73%. In terms of these variables, the performance of the ensemble model is superior to that of both the orthopedic attending physician group and the radiology attending physician group. ConclusionThis deep learning ensemble model has excellent performance in detecting DRFs on plain X-ray films. Using this artificial intelligence model as a second expert to assist clinical diagnosis is expected to improve the accuracy of diagnosing DRFs and enhance clinical work efficiency.
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MethodsA total of 3,240 patients (fracture: n = 1,620, normal: n = 1,620) were included in this study, with a total of 3,276 wrist joint anteroposterior (AP) X-ray films (1,639 fractured, 1,637 normal) and 3,260 wrist joint lateral X-ray films (1,623 fractured, 1,637 normal). We divided the patients into training set, validation set and test set in a ratio of 7:1.5:1.5. The deep learning models were developed using the data from the training and validation sets, and then their effectiveness were evaluated using the data from the test set. Evaluate the diagnostic performance of deep learning models using receiver operating characteristic (ROC) curves and area under the curve (AUC), accuracy, sensitivity, and specificity, and compare them with medical professionals. ResultsThe deep learning ensemble model had excellent accuracy (97.03%), sensitivity (95.70%), and specificity (98.37%) in detecting DRFs. Among them, the accuracy of the AP view was 97.75%, the sensitivity 97.13%, and the specificity 98.37%; the accuracy of the lateral view was 96.32%, the sensitivity 94.26%, and the specificity 98.37%. When the wrist joint is counted, the accuracy was 97.55%, the sensitivity 98.36%, and the specificity 96.73%. In terms of these variables, the performance of the ensemble model is superior to that of both the orthopedic attending physician group and the radiology attending physician group. ConclusionThis deep learning ensemble model has excellent performance in detecting DRFs on plain X-ray films. Using this artificial intelligence model as a second expert to assist clinical diagnosis is expected to improve the accuracy of diagnosing DRFs and enhance clinical work efficiency.</description><identifier>ISSN: 2296-858X</identifier><identifier>EISSN: 2296-858X</identifier><identifier>DOI: 10.3389/fmed.2023.1224489</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>artificial intelligence ; computer-assisted diagnosis ; deep learning ; distal radius fractures ; elderly population groups ; Medicine</subject><ispartof>Frontiers in medicine, 2023-08, Vol.10, p.1224489-1224489</ispartof><rights>Copyright © 2023 Zhang, Li, Lin, Xue, Wang, Fang, Liu, Huo, Zhou, Yang, Xie, Xie, Lu, Liu and Ye. 2023 Zhang, Li, Lin, Xue, Wang, Fang, Liu, Huo, Zhou, Yang, Xie, Xie, Lu, Liu and Ye</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-c9f23efcae2ec9f270db7a96cb4e3895075b3b9f6ef40f055074e064e3ad8fc3</citedby><cites>FETCH-LOGICAL-c443t-c9f23efcae2ec9f270db7a96cb4e3895075b3b9f6ef40f055074e064e3ad8fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471443/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471443/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Zhang, Jiayao</creatorcontrib><creatorcontrib>Li, Zhimin</creatorcontrib><creatorcontrib>Lin, Heng</creatorcontrib><creatorcontrib>Xue, Mingdi</creatorcontrib><creatorcontrib>Wang, Honglin</creatorcontrib><creatorcontrib>Fang, Ying</creatorcontrib><creatorcontrib>Liu, Songxiang</creatorcontrib><creatorcontrib>Huo, Tongtong</creatorcontrib><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Yang, Jiaming</creatorcontrib><creatorcontrib>Xie, Yi</creatorcontrib><creatorcontrib>Xie, Mao</creatorcontrib><creatorcontrib>Lu, Lin</creatorcontrib><creatorcontrib>Liu, Pengran</creatorcontrib><creatorcontrib>Ye, Zhewei</creatorcontrib><title>Deep learning assisted diagnosis system: improving the diagnostic accuracy of distal radius fractures</title><title>Frontiers in medicine</title><description>ObjectivesTo explore an intelligent detection technology based on deep learning algorithms to assist the clinical diagnosis of distal radius fractures (DRFs), and further compare it with human performance to verify the feasibility of this method. MethodsA total of 3,240 patients (fracture: n = 1,620, normal: n = 1,620) were included in this study, with a total of 3,276 wrist joint anteroposterior (AP) X-ray films (1,639 fractured, 1,637 normal) and 3,260 wrist joint lateral X-ray films (1,623 fractured, 1,637 normal). We divided the patients into training set, validation set and test set in a ratio of 7:1.5:1.5. The deep learning models were developed using the data from the training and validation sets, and then their effectiveness were evaluated using the data from the test set. Evaluate the diagnostic performance of deep learning models using receiver operating characteristic (ROC) curves and area under the curve (AUC), accuracy, sensitivity, and specificity, and compare them with medical professionals. ResultsThe deep learning ensemble model had excellent accuracy (97.03%), sensitivity (95.70%), and specificity (98.37%) in detecting DRFs. Among them, the accuracy of the AP view was 97.75%, the sensitivity 97.13%, and the specificity 98.37%; the accuracy of the lateral view was 96.32%, the sensitivity 94.26%, and the specificity 98.37%. When the wrist joint is counted, the accuracy was 97.55%, the sensitivity 98.36%, and the specificity 96.73%. In terms of these variables, the performance of the ensemble model is superior to that of both the orthopedic attending physician group and the radiology attending physician group. ConclusionThis deep learning ensemble model has excellent performance in detecting DRFs on plain X-ray films. Using this artificial intelligence model as a second expert to assist clinical diagnosis is expected to improve the accuracy of diagnosing DRFs and enhance clinical work efficiency.</description><subject>artificial intelligence</subject><subject>computer-assisted diagnosis</subject><subject>deep learning</subject><subject>distal radius fractures</subject><subject>elderly population groups</subject><subject>Medicine</subject><issn>2296-858X</issn><issn>2296-858X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkT9v2zAQxYWgBWo4-QDdOGaxy38SxS5FkKStgQBZMnQjTtTRpiGJDikF8LcPVTtFPfH43vFHHl9RfGV0LUStv7ke2zWnXKwZ51LW-qpYcK6rVV3Wfz79V38pblLaU0qZ4KVkYlHgA-KBdAhx8MOWQEo-jdiS1sN2CHlD0jEL_Xfi-0MMb3PTuMMPf_SWgLVTBHskwWU5jdCRCK2fEnFZHqeI6br47KBLeHNel8XLz8eX-9-rp-dfm_u7p5WVUowrqx0X6Cwgx7lWtG0U6Mo2EvOcJVVlIxrtKnSSOlpmQSKtsglt7axYFpsTtg2wN4foe4hHE8Cbv0KIWwMxP7lDY8HmU8BRaZSysTWWoDQrtaqtZrzJrB8n1mFq8vdaHMYI3QX00hn8zmzDm2FUKpbHyYTbMyGG1wnTaHqfLHYdDBimZHhd0YopVZW5lZ1abQwpRXT_7mHUzBGbOWIzR2zOEYt3aruenQ</recordid><startdate>20230817</startdate><enddate>20230817</enddate><creator>Zhang, Jiayao</creator><creator>Li, Zhimin</creator><creator>Lin, Heng</creator><creator>Xue, Mingdi</creator><creator>Wang, Honglin</creator><creator>Fang, Ying</creator><creator>Liu, Songxiang</creator><creator>Huo, Tongtong</creator><creator>Zhou, Hong</creator><creator>Yang, Jiaming</creator><creator>Xie, Yi</creator><creator>Xie, Mao</creator><creator>Lu, Lin</creator><creator>Liu, Pengran</creator><creator>Ye, Zhewei</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230817</creationdate><title>Deep learning assisted diagnosis system: improving the diagnostic accuracy of distal radius fractures</title><author>Zhang, Jiayao ; Li, Zhimin ; Lin, Heng ; Xue, Mingdi ; Wang, Honglin ; Fang, Ying ; Liu, Songxiang ; Huo, Tongtong ; Zhou, Hong ; Yang, Jiaming ; Xie, Yi ; Xie, Mao ; Lu, Lin ; Liu, Pengran ; Ye, Zhewei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-c9f23efcae2ec9f270db7a96cb4e3895075b3b9f6ef40f055074e064e3ad8fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>artificial intelligence</topic><topic>computer-assisted diagnosis</topic><topic>deep learning</topic><topic>distal radius fractures</topic><topic>elderly population groups</topic><topic>Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jiayao</creatorcontrib><creatorcontrib>Li, Zhimin</creatorcontrib><creatorcontrib>Lin, Heng</creatorcontrib><creatorcontrib>Xue, Mingdi</creatorcontrib><creatorcontrib>Wang, Honglin</creatorcontrib><creatorcontrib>Fang, Ying</creatorcontrib><creatorcontrib>Liu, Songxiang</creatorcontrib><creatorcontrib>Huo, Tongtong</creatorcontrib><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Yang, Jiaming</creatorcontrib><creatorcontrib>Xie, Yi</creatorcontrib><creatorcontrib>Xie, Mao</creatorcontrib><creatorcontrib>Lu, Lin</creatorcontrib><creatorcontrib>Liu, Pengran</creatorcontrib><creatorcontrib>Ye, Zhewei</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Frontiers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jiayao</au><au>Li, Zhimin</au><au>Lin, Heng</au><au>Xue, Mingdi</au><au>Wang, Honglin</au><au>Fang, Ying</au><au>Liu, Songxiang</au><au>Huo, Tongtong</au><au>Zhou, Hong</au><au>Yang, Jiaming</au><au>Xie, Yi</au><au>Xie, Mao</au><au>Lu, Lin</au><au>Liu, Pengran</au><au>Ye, Zhewei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deep learning assisted diagnosis system: improving the diagnostic accuracy of distal radius fractures</atitle><jtitle>Frontiers in medicine</jtitle><date>2023-08-17</date><risdate>2023</risdate><volume>10</volume><spage>1224489</spage><epage>1224489</epage><pages>1224489-1224489</pages><issn>2296-858X</issn><eissn>2296-858X</eissn><abstract>ObjectivesTo explore an intelligent detection technology based on deep learning algorithms to assist the clinical diagnosis of distal radius fractures (DRFs), and further compare it with human performance to verify the feasibility of this method. MethodsA total of 3,240 patients (fracture: n = 1,620, normal: n = 1,620) were included in this study, with a total of 3,276 wrist joint anteroposterior (AP) X-ray films (1,639 fractured, 1,637 normal) and 3,260 wrist joint lateral X-ray films (1,623 fractured, 1,637 normal). We divided the patients into training set, validation set and test set in a ratio of 7:1.5:1.5. The deep learning models were developed using the data from the training and validation sets, and then their effectiveness were evaluated using the data from the test set. Evaluate the diagnostic performance of deep learning models using receiver operating characteristic (ROC) curves and area under the curve (AUC), accuracy, sensitivity, and specificity, and compare them with medical professionals. ResultsThe deep learning ensemble model had excellent accuracy (97.03%), sensitivity (95.70%), and specificity (98.37%) in detecting DRFs. Among them, the accuracy of the AP view was 97.75%, the sensitivity 97.13%, and the specificity 98.37%; the accuracy of the lateral view was 96.32%, the sensitivity 94.26%, and the specificity 98.37%. When the wrist joint is counted, the accuracy was 97.55%, the sensitivity 98.36%, and the specificity 96.73%. In terms of these variables, the performance of the ensemble model is superior to that of both the orthopedic attending physician group and the radiology attending physician group. ConclusionThis deep learning ensemble model has excellent performance in detecting DRFs on plain X-ray films. Using this artificial intelligence model as a second expert to assist clinical diagnosis is expected to improve the accuracy of diagnosing DRFs and enhance clinical work efficiency.</abstract><pub>Frontiers Media S.A</pub><doi>10.3389/fmed.2023.1224489</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects artificial intelligence
computer-assisted diagnosis
deep learning
distal radius fractures
elderly population groups
Medicine
title Deep learning assisted diagnosis system: improving the diagnostic accuracy of distal radius fractures
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