Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats

Innovative drug-delivery systems offer a unique approach to effectively provide therapeutic drug dose over the needed time to achieve better tissue protection and enhanced recovery. The hypothesis of the current study was to test the antioxidant and anti-inflammatory effects of genistein and nanofib...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicines 2018-10, Vol.6 (4), p.96
Main Authors: Ismail, Mohamed, Ibrahim, Sara, El-Amir, Azza, El-Rafei, Amira M, Allam, Nageh K, Abdellatif, Ahmed
Format: Article
Language:English
Subjects:
Antioxidants
Chitosan
Cytokines
Drug delivery systems
Estrogens
Free radicals
Genistein
IL-10
Inflammation
inflammation SCI
Injuries
Interleukin 10
Lipid peroxidation
Lipids
Malondialdehyde
MDA
nanofibers
Nervous system
Nitric oxide
Nitrous oxide
Oxidative stress
Polyvinyl alcohol
SOD
Spinal cord
Spinal cord injuries
spinal cord injury
TNF-α
Trauma
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Innovative drug-delivery systems offer a unique approach to effectively provide therapeutic drug dose over the needed time to achieve better tissue protection and enhanced recovery. The hypothesis of the current study was to test the antioxidant and anti-inflammatory effects of genistein and nanofibers on the spinal cord tissue following experimental spinal cord injury (SCI). Rats were treated post SCI with genistein that is loaded on chitosan/polyvinyl alcohol (CS/PVA) nanofibers as an implantable drug-delivery system. SCI caused marked oxidative damage and inflammation, as is evident by the reduction in the super oxide dismutase (SOD) activity and the level of interleukin-10 (IL-10) in injured spinal cord tissue, as well as the significant increase in the levels of nitric oxide (NO), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-α). Treatment of rats post SCI with genistein and CS/PVA nanofibers improved most of the above-mentioned biochemical parameters and shifted them toward the control group values. Genistein induced an increase in the activity of SOD and the level of IL-10, while causing a decrease in NO, MDA, and TNF-α in injured spinal cord tissue. Genistein and CS/PVA nanofibers provide a novel combination for treating inflammatory nervous tissue conditions, especially when combined as an implantable drug-delivery system.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines6040096