Chronological changes of incidence and prognosis of children with asymptomatic congenital cytomegalovirus infection in Sapporo, Japan

Chronological changes of the incidence of congenital cytomegalovirus (CMV) infection and the longitudinal prognosis in children with asymptomatic congenital infection were investigated. Congenital CMV infection, as demonstrated by isolation of the virus within the first week of life, was diagnosed i...

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Bibliographic Details
Published in:BMC infectious diseases 2004-07, Vol.4 (1), p.22-22, Article 22
Main Authors: Numazaki, Kei, Fujikawa, Tomoko
Format: Article
Language:English
Subjects:
Case-Control Studies
CD4-Positive T-Lymphocytes - immunology
Child Development
Child, Preschool
congenital infection
Cytokines - analysis
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - epidemiology
Evoked Potentials, Auditory, Brain Stem
Hearing Loss, Sensorineural - epidemiology
Hearing Loss, Sensorineural - etiology
Humans
Incidence
Infant
Infant, Newborn
Intelligence Tests
intracellular cytokine
Japan - epidemiology
Longitudinal Studies
Prognosis
sensorineural hearing loss
Urine - virology
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Summary:Chronological changes of the incidence of congenital cytomegalovirus (CMV) infection and the longitudinal prognosis in children with asymptomatic congenital infection were investigated. Congenital CMV infection, as demonstrated by isolation of the virus within the first week of life, was diagnosed in infants born in Sapporo, Japan, during the 26-year period between 1977 and 2002. Congenital infection was diagnosed in 37 (0.31%) of 11,938 infants. Thirty-two infants were (86.5%) asymptomatic and 5 (13.5%) were symptomatic at birth. Although a decrease in the total incidence of congenital CMV infection has been seen in recent years, screening of congenital infection at birth seems to be necessary to detect late-onset neurodevelopmental sequelae.
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-4-22