Caspase-8 in inflammatory diseases: a potential therapeutic target

Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory role in extrinsic apoptosis. With advancing research, a growing body of evidence has substantiated its involvement in other cell death processes, such as pyroptosis and necropto...

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Published in:Cellular & molecular biology letters 2024-10, Vol.29 (1), p.130-46, Article 130
Main Authors: Zhang, Wangzheqi, Zhu, Chenglong, Liao, Yan, Zhou, Miao, Xu, Wenyun, Zou, Zui
Format: Article
Language:English
Subjects:
Adapter proteins
Amino acids
Animals
Apoptosis
Aspartic endopeptidase
Autoimmune diseases
Cancer
Caspase 8 - genetics
Caspase 8 - metabolism
Caspase-8
Cell activation
Cell death
Cell survival
Competition
Cytokines
Enzymatic activity
Humans
Immune system
Inflammasomes
Inflammasomes - metabolism
Inflammation
Inflammatory disease
Inflammatory diseases
Kinases
Necroptosis
Necroptosis - genetics
Neoplasms - enzymology
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - genetics
PANoptosis
Pyroptosis
Review
Roles
Sepsis
Therapeutic targets
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Summary:Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory role in extrinsic apoptosis. With advancing research, a growing body of evidence has substantiated its involvement in other cell death processes, such as pyroptosis and necroptosis, as well as its modulatory effects on inflammasomes and proinflammatory cytokines. PANoptosis, an emerging concept of cell death, encompasses pyroptosis, apoptosis, and necroptosis, providing insight into the often overlapping cellular mortality observed during disease progression. The activation or deficiency of caspase-8 enzymatic activity is closely linked to PANoptosis, positioning caspase-8 as a key regulator of cell survival or death across various physiological and pathological processes. Aberrant expression of caspase-8 is closely associated with the development and progression of a range of inflammatory diseases, including immune system disorders, neurodegenerative diseases (NDDs), sepsis, and cancer. This paper delves into the regulatory role and impact of caspase-8 in these conditions, aiming to elucidate potential therapeutic strategies for the future intervention.
ISSN:1689-1392
1425-8153
1689-1392
DOI:10.1186/s11658-024-00646-x