Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

Background The treatment, and efficacy thereof, is considered to be inadequate with specificity to alleviation of Fibromyalgia and its associated pain. Fibromyalgia patients suffer from chronic and persistent widespread pain and generalized tenderness. Transient receptor potential V1 (TRPV1), which...

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Bibliographic Details
Published in:Chinese medicine 2021-06, Vol.16 (1), p.1-43, Article 43
Main Authors: Liao, Hsien-Yin, Lin, Yi-Wen
Format: Article
Language:English
Subjects:
Acupuncture
Analgesics
Analysis
B cells
Calcium permeability
Capsaicin receptors
Care and treatment
Cerebellum
Cold
Electroacupuncture
Experiments
Fibromyalgia
Hypothalamus
Inflammation
Kinases
Laboratory animals
Microglia
Nervous system
Pain
Pain perception
Periaqueductal gray area
Proteins
Signal transduction
Spinal cord
Stainless steel
Therapeutic targets
Transient receptor potential proteins
TRPV1
Tumor necrosis factor-TNF
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Summary:Background The treatment, and efficacy thereof, is considered to be inadequate with specificity to alleviation of Fibromyalgia and its associated pain. Fibromyalgia patients suffer from chronic and persistent widespread pain and generalized tenderness. Transient receptor potential V1 (TRPV1), which is reported as a Ca.sup.2+ permeable ion channel that can be activated by inflammation, is reported to be involved in the development of fibromyalgia pain. Methods The current study explored the TRPV1 channel functions as a noxious sensory input in mice cold stress model. It remains unknown whether electroacupuncture (EA) attenuates fibromyalgia pain or affects the TRPV1 pathway. Results We show that cold stress increases mechanical and thermal pain (day 7: mechanical: 1.69 [+ or -] 0.41 g; thermal: 4.68 [+ or -] 0.56 s), and that EA and Trpv1 deletion counter this increase. EA and Trpv1 deletion reduced the cold stress-induced increase in inflammatory mediators and TRPV1-related molecules in the hypothalamus, periaqueductal gray (PAG), and cerebellum of mice. Conclusions Our results imply that EA has an analgesic effect associated with TRPV1 downregulation. We provide novel evidence that these inflammatory mediators can modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for fibromyalgia pain. Keywords: Electroacupuncture, Fibromyalgia, Microglia, TRPV1, Hypothalamus, Cerebellum
ISSN:1749-8546
1749-8546
DOI:10.1186/s13020-021-00451-0