Influenza season influence on outcome of new nodules in the NELSON study

• Published in: Scientific reports 2023-04, Vol.13 (1), p.6589-6589, Article 6589
• Main Authors: Lancaster, H. L., Heuvelmans, M. A., de Bock, G. H., Du, Y., Mohamed Hoesein, F. A. A., Nackaerts, K., Walter, J. E., Vliegenthart, R., Oudkerk, M.
• Format: Article
• Language: English
• Subjects: 692/4028/67/1612; 692/4028/67/2322; Cancer screening; Early Detection of Cancer; Hay fever; Humanities and Social Sciences; Humans; Influenza; Influenza, Human - epidemiology; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - epidemiology; Lung nodules; Medical screening; multidisciplinary; Multiple Pulmonary Nodules - epidemiology; Science; Science (multidisciplinary); Seasons; Solitary Pulmonary Nodule; Statistical analysis; Summer; Tomography, X-Ray Computed; Winter
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-33672-4

We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00–1.15], p  = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95–1.98], p  = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18–1.23], p  = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.