Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventions

• Published in: Cell death discovery 2024-09, Vol.10 (1), p.398-16, Article 398
• Main Authors: Ouyang, Weijie, Yan, Dan, Hu, Jiaoyue, Liu, Zuguo
• Format: Article
• Language: English
• Subjects: 692/308/53; 692/699/3161; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; DNA damage; Eye; Homeostasis; Inflammation; Life Sciences; Medical innovations; Mitochondrial DNA; Oxidative stress; Public health; Quality of life; Review Article; Stem Cells; Therapeutic targets
• ISSN: 2058-7716; 2058-7716
• DOI: 10.1038/s41420-024-02159-0

Dry eye, recognized as the most prevalent ocular surface disorder, has risen to prominence as a significant public health issue, adversely impacting the quality of life for individuals across the globe. Despite decades of extensive research into the chronic inflammation that characterizes dry eye, the intricate mechanisms fueling this persistent inflammatory state remain incompletely understood. Among the various cellular components under investigation, mitochondria—essential for cellular energy production and homeostasis—have attracted increasing attention for their role in dry eye pathogenesis. This involvement points to mechanisms such as oxidative stress, apoptosis, and sustained inflammation, which are central to the progression of the disease. This review aims to provide a thorough exploration of mitochondrial dysfunction in dry eye, shedding light on the critical roles played by mitochondrial oxidative stress, apoptosis, and mitochondrial DNA damage. It delves into the mechanisms through which diverse pathogenic factors may trigger mitochondrial dysfunction, thereby contributing to the onset and exacerbation of dry eye. Furthermore, it lays the groundwork for an overview of current therapeutic strategies that specifically target mitochondrial dysfunction, underscoring their potential in managing this complex condition. By spotlighting this burgeoning area of research, our review seeks to catalyze the development of innovative drug discovery and therapeutic approaches. The ultimate goal is to unlock promising avenues for the future management of dry eye, potentially revolutionizing treatment paradigms and improving patient outcomes. Through this comprehensive examination, we endeavor to enrich the scientific community’s understanding of dry eye and inspire novel interventions that address the underlying mitochondrial dysfunctions contributing to this widespread disorder.