Serum Malondialdehyde-Modified Low-Density Lipoprotein Is a Risk Factor for Central Arterial Stiffness in Maintenance Hemodialysis Patients

• Published in: Nutrients 2020-07, Vol.12 (7), p.2160
• Main Authors: Hou, Jia-Sian, Wang, Chih-Hsien, Lai, Yu-Hsien, Kuo, Chiu-Huang, Lin, Yu-Li, Hsu, Bang-Gee, Tsai, Jen-Pi
• Format: Article
• Language: English
• Subjects: Aged; Aorta; aortic stiffness; Arteriosclerosis; Atherosclerosis; Atherosclerosis - diagnosis; Atherosclerosis - etiology; Atherosclerosis - physiopathology; Biomarkers - blood; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Carotid Arteries - physiopathology; carotid-femoral pulse wave velocity; Coronary vessels; Diabetes Mellitus; Electrocardiography; Enzyme-linked immunosorbent assay; Female; Femoral Artery - physiopathology; Hemodialysis; Humans; Hypertension; Lipoproteins; Lipoproteins, LDL - blood; Low density lipoprotein; Male; Malondialdehyde; Malondialdehyde - blood; malondialdehyde-modified low-density lipoprotein; Middle Aged; Multivariable control; Normal distribution; Oxidative Stress; Pulse Wave Analysis; Regression analysis; Renal Dialysis - adverse effects; Risk analysis; Risk Factors; Software; Stiffness; Values; Vascular Stiffness; Wave velocity
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12072160

Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) acts as a marker of oxidative stress and is associated with atherosclerotic cardiovascular disease. The relationship between serum MDA-LDL levels and aortic stiffness (AS) in patients with hemodialysis (HD) was evaluated. There were 155 HD patients enrolled in this study. Carotid-femoral pulse wave velocity (cfPWV) was measured by a validated tonometry system. Patients with cfPWV >10 m/s were used to define the AS group, while those with values of ≤10 m/s were regarded as the control group. Serum MDA-LDL levels were measured using a commercial enzyme-linked immunosorbent assay. Sixty-eight patients (43.9%) who were defined as AS sufferers, and were older, had a higher percentage of diabetes and hypertension and higher systolic blood pressure and serum MDA-LDL level compared to subjects in the control group. After adjusting for factors significantly associated with AS by multivariable logistic regression analysis, it was revealed that serum MDA-LDL levels, diabetes, and hypertension were independent predictors of AS in HD patients. Multivariable forward stepwise linear regression analysis also showed that a logarithmically transformed MDA-LDL level was significantly correlated with cfPWV values in HD patients. In HD patients, a high serum MDA-LDL level was positively associated with cfPWV values and was a significant predictor of the development of high AS.