Exploring Mitochondrial Heterogeneity and Evolutionary Dynamics in Thelephora ganbajun through Population Genomics

Limited exploration in fungal mitochondrial genetics has uncovered diverse inheritance modes. The mitochondrial genomes are inherited uniparentally in the majority of sexual eukaryotes, our discovery of persistent mitochondrial heterogeneity within the natural population of the basidiomycete fungus...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-08, Vol.25 (16), p.9013
Main Authors: Li, Haixia, Liang, Tong, Liu, Yongju, Wang, Pengfei, Wang, Shaojuan, Zhao, Min, Zhang, Ying
Format: Article
Language:English
Subjects:
Basidiomycota - genetics
Cloning
comparative population genomics
DNA, Mitochondrial - genetics
Enzymes
Evolution, Molecular
Fungi
Gene Transfer, Horizontal
Genes
Genetic diversity
Genetic engineering
Genome, Mitochondrial
Genomes
Genomics
Genomics - methods
Introns - genetics
Mitochondria
Mitochondria - genetics
Mitochondrial DNA
mitogenome
Mushrooms
persistent heteroplasmy
Phylogeny
wild edible fungi
Yeast
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Summary:Limited exploration in fungal mitochondrial genetics has uncovered diverse inheritance modes. The mitochondrial genomes are inherited uniparentally in the majority of sexual eukaryotes, our discovery of persistent mitochondrial heterogeneity within the natural population of the basidiomycete fungus represents a significant advance in understanding mitochondrial inheritance and evolution in eukaryotes. Here, we present a comprehensive analysis by sequencing and assembling the complete mitogenomes of 40 samples exhibiting diverse heterogeneity patterns from various geographical origins. Additionally, we identified heterogeneous variants in the gene, which, similar to , displayed variability across multiple copies. Notably, our study reveals a distinct prevalence of introns and homing endonucleases in these heterogeneous genes. Furthermore, we detected potential instances of horizontal gene transfer involving homing endonucleases. Population genomic analyses underscore regional variations in mitochondrial genome composition among natural samples exhibiting heterogeneity. Thus, polymorphisms in heterogeneous genes, introns, and homing endonucleases significantly influence mitochondrial structure, structural variation, and evolutionary dynamics in this species. This study contributes valuable insights into mitochondrial genome architecture, population dynamics, and the evolutionary implications of mitochondrial heterogeneity in sexual eukaryotes.
ISSN:1661-6596
1422-0067
1422-0067
DOI:10.3390/ijms25169013