Structure-Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy

• Published in: Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2019-11, Vol.13, p.2181-2188
• Main Authors: Alonso-Plasencia, Marta, Abreu-González, Rodrigo, Gómez-Culebras, Mario Alberto
• Format: Article
• Language: English
• Subjects: Angiography; Diabetes; Diabetic retinopathy; Diabetics; Diagnostic imaging; Edema; Lasers; Medical imaging; Morphology; Original Research; Patients; Political activity; Political aspects; Retina; retinal sensitity; Tomography; Topography; Tropicamide; vessel density
• ISSN: 1177-5467; 1177-5483; 1177-5483
• DOI: 10.2147/opth.s220877

To evaluate macular vasculature in diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and to correlate vessel density (VD) with retinal sensitivity (RS) as a way to assess structural and functional findings in DR. Prospective observational cross-sectional study. Diabetic patients with DR but no clinically significant diabetic macular edema (DME) and healthy subjects were included in this study. All of them underwent comprehensive ophthalmic examination, best corrected visual acuity (BCVA), OCTA with RS-3000 Advance AngioScan (Nidek, Gamagori, Japan) and microperimetry with MP-3 (Nidek, Gamagori, Japan). Retinal vascular density measured by OCT angiography in 9 areas was correlated with RS in the same 9 areas by Spearman correlation. In this study, 50 subjects were enrolled: 25 eyes of diabetic patients with DR and 25 eyes of non-diabetic subjects. Diabetic patients mean age was 51.88±13.62 years; non-diabetic subjects were 43.48±13.42 years. The BCVA was 20/25 in the diabetic group and 20/20 in the non-diabetic group. Mean RS was decreased in the DR group (27.68±2.71 dB) compared to the non-diabetic group (31.68±1.46 dB) (p